APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.

GKT136901是一种选择性的 NADPH 氧化酶 NOX-1/4 抑制剂，Ki 值分别为 160 和 165 nM，具有抗炎和抗氧化活性，适用于糖尿病肾病、中风和神经退行性疾病的研究，还具有清除过氧亚硝酸盐的作用。

Fluoflavine是一种选择性 NOX1 抑制剂 (IC₅₀ = 90 nM)，其选择性是 NOX2、NOX3、NOX4 的 100 倍以上，适用于抗氧化应激和炎症相关的研究，尤其在神经退行性疾病和肿瘤中的应用潜力广泛。

APX-115是一种 HIV-1 Nef 蛋白抑制剂，能有效竞争 Nef-SH3Hck 的相互作用，其 Kd 为 6.7 μM。

GLX351322是一种 NADPH 氧化酶 4 (Nox4) 抑制剂，抑制过表达 NOX4 细胞的过氧化氢生成，IC50 为 5 μM。

VAS 3947是一种特异性的 NADPH 氧化酶 (NOX) 抑制剂，具有抗血小板活性，并能诱导细胞凋亡。

GKT137831（Setanaxib）是一种选择性的NADPH氧化酶（NOX1/4）抑制剂，Ki值分别为140 nM和110 nM。

ML171 (2-Acetylphenothiazine; 2-APT)是一种有效且选择性的NADPH氧化酶1（Nox1）抑制剂，在HEK293-Nox1确认实验中抑制Nox1依赖的ROS生成，IC50为0.25 μM。

GSK2795039是一种NADPH氧化酶2（NOX2）抑制剂，在各种无细胞测定中的平均pIC50为6。它抑制活性氧（ROS）的生成和NADPH的消耗，并减少细胞凋亡。

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting AKF-PD is a potential novel therapeutic agent against renal fibrosis.

Phox-I2是一种选择性的 p67phox-Rac1 相互作用抑制剂，Kd 约为 150 nM。该化合物可抑制 NADPH 氧化酶 2 (NOX2) 的活性，减少活性氧 (ROS) 的产生，适用于抗炎症和抗氧化相关研究。

Apocynin是一种选择性的 NADPH 氧化酶抑制剂，IC50 为 10 μM。在卡拉胶诱导的胸膜炎小鼠模型中改善急性肺炎症，可用于癌症研究，并通过逆转间充质干细胞衰老促进成骨作用并增加骨量。

8-Epideoxyloganic acid, a natural product isolated and purified from the herb of Lamiophlomis rotata, with anti-inflammatory activity, weak antinociceptive activity and bioactivities of analgesia, homeostasis, has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activity and/or the radical scavenging effect, and beta2 integrin expression in leucocytes.

Rehmannic acid, a natural product isolated and purified from the herbs of Lantana camara, inhibit succinoxidase activity, and is a potent uncoupler, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.

4beta-Carboxy-19-nortotarol, a natural product isolated and purified from the heartwoods of Podocarpus macrophyllus, can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH. It inhibits linoleic acid autoxidation but not generation of superoxide anion.