Alkannin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.

Dimethylacrylshikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc. with anti-proliferate activity, is a promising agent for developing an improved strategy for radiotherapy against tumors.

β-Hydroxyisovalerylshikonin是从Lithospermum erythrorhizon中分离出的一种天然产物，作为有效的PTK抑制剂，针对EGFR和v-Src的IC₅₀值分别为0.7 μM和1 μM，能显著抑制多种肿瘤细胞系的增殖，并诱导肿瘤细胞死亡。

Deoxyshikonin通过 PI3K/Akt/mTOR 通路抑制结直肠癌 (CRC)。它具有促血管生成和抗肿瘤效果，并对金黄色葡萄球菌 (MRSA) 和肺炎链球菌表现出抗菌活性（MIC=17 μg/mL）。

(Rac)-Shikonin是一种天然产物，具有强效的抗肿瘤活性，能够绕过癌症耐药性。

Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor.

Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent.

Griffonin is an extract from the roots of Semiquilegia adoxides which display anti-neutrophilic inflammatory activity.

beta,beta-Dimethylacrylalkannin, a natural product isolated and purified from the roots of Lithospermum erythrorhizon with radical scavenging activity, can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin, shows remarkable cytotoxic activity against HT-29, MDA-MB-231 and PC-3 cell lines, comparable or stronger than the other compounds and positive control CPT-11 (CAMPTOSTAR®, irinotecan) with IC50 values in between 0.1uM and 1uM and it has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value, and exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 μMol·L-1.

Shikonofuran A is a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc..

Isobutylshikonin is found in roots of lithosperraum erythrorhizon sieb. et Zucc. which exhibits obvious antioxidant activities.