UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].

Glutaminase C-IN-1 is an allosteric inhibitor of glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts.