Thalidomide-5-CH2-NH2 HCl是基于 Thalidomide 的 cereblon 配体，可用于招募 CRBN 蛋白，通过连接剂与蛋白配体结合，生成 PROTACs。

SY2-062 is a bromo substituted E3 Ligand for CRBN, structurally similar to Pomalidomide.

WUN29654 is a CRBN modulator with CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 value of ~21.53μM.

Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.

Pomalidomide是一种第三代免疫调节剂，通过与 E3 连接酶 cereblon 相互作用并诱导必需的 Ikaros 转录因子降解，作为分子胶作用。

E3 ligase Ligand 2 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.

TC E3 5032 is a thalidomide derivate for conjugation reactions of PROTAC, which can hijack cereblon as the E3 ubiquitin ligase component.