KM11060 是 F508 缺失-囊性纤维化跨膜电导调节剂 (F508del-CFTR) 转运缺陷的校正剂。KM11060 可用于 F508del-CFTR 加工缺陷的研究和囊性纤维化研究剂的开发。

UCCF-853是一种囊性纤维化跨膜电导调节蛋白（CFTR）的调节剂，具有潜在的应用于囊性纤维化等疾病研究的价值。

CFTR corrector 9是一种 CFTR 调节剂，主要用于囊性纤维化 (CF) 和其他 CFTR 相关疾病的研究，能够纠正 CFTR 蛋白的功能缺陷，恢复其正常的跨膜传导功能。

Icenticaftor是一种 CFTR 通道增强剂，专门用于改善 CFTR 功能。它在治疗囊性纤维化等遗传性疾病中具有重要的临床意义。

SRI-41315通过诱导终止密码子的长时间停顿，抑制与囊性纤维化相关的过早终止密码子 (PTCs)，恢复CFTR蛋白的表达和功能。SRI-41315 通过减少终止因子eRF1的丰度，同时增强氨基糖苷介导的通读，显著提升CFTR的活性。

PPQ-102 is a potent and voltage-independent CFTR inhibitor, which completely inhibit CFTR chloride current with IC50 approximately 90 nM.

CFTR (inh)-172 is an reversibly inhibitor of CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with Ki ~300 nM.

Fenamic acid是一种具有口服活性的氯通道阻滞剂。Fenamic acid 是一种非甾体抗炎药（NSAID）的基本结构，用于研究抗炎和镇痛特性，对各种炎症和疼痛症状具有治疗效果。

GLPG-1837 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator1, shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.

Ivacaftor is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

Xipamide, a sulfonamide diuretic drug, can block sodium reabsorption in distal tubules of the kidney and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. It is used for the treatment of oedema and hypertension.

IOWH-032 is a potent CFTR inhibitor (IC50=1.01 μM) in T84 and CHO-CFTR cell based assays.

GlyH-101, a glycinyl hydrazone compound, is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 4.3 μM.

CFTR corrector 2是囊性纤维化跨膜电导调节因子 (CFTR) 的调节剂，CFTR 是一种位于上皮细胞膜上的氯离子通道，对盐和液体的稳态至关重要。

Elexacaftor（VX-445）是一种囊性纤维化跨膜传导调节因子（CFTR）调节剂。它促进CFTR的加工和运输，增加其在细胞表面的存在。

VX-661 is a F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.

Lumacaftor (VX-809; VRT 826809) 是一种CFTR调节剂，可纠正CFTR蛋白的折叠和运输。

PTC-124 is nonsense allele inhibitor, used to treat Duchenne muscular dystrophy.

Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.

5,7,4'-三甲氧基黄酮可以从药用植物Kaempferia parviflora（Kaempferia parviflora, KP）中分离出来。它作为 CFTR 激活剂，其 EC50 为 64 μM。