MZ1是一种高效、选择性的PROTAC分子，能够靶向BRD4和VHL E3泛素连接酶，将BRD4蛋白降解。MZ1通过诱导BRD4降解，在癌症等表观遗传疾病的研究中显示出潜力。

dBET1 is a PROTAC, consisting of a BRD4-ligand JQ-1 linkerd to a cereblon E3 ligase ligand, targeting on BET bromodomain BRD4

ARV-825是一种PROTAC，连接Cereblon和BRD4的配体，结合BRD4的BD1和BD2，Kd值分别为90 nM和28 nM。

A1874 is a nutlin-based PROTAC targeting on BRD4, consist of a BRD4-ligand JQ1 linked to a MDM2 E3 ligase ligand RG7388.

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM).

AT6 is a PROTAC targeting on Brd4.

TD-428 is a PROTAC targeting on pan-BET with DC₅₀ of 0.32nM for BRD4, consist of BET inhibitor, JQ1, as a warhead linked to CRBN modulator TD-106 as the E3 ligase ligand.