MZ1是一种高效、选择性的PROTAC分子，能够靶向BRD4和VHL E3泛素连接酶，将BRD4蛋白降解。MZ1通过诱导BRD4降解，在癌症等表观遗传疾病的研究中显示出潜力。

dBET1是一种 PROTAC，由 BRD4 配体 JQ-1 和 cereblon E3 连接酶配体组成，靶向 BET 溴结构域 BRD4。

ARV-825是一种PROTAC，连接Cereblon和BRD4的配体，结合BRD4的BD1和BD2，Kd值分别为90 nM和28 nM。

A1874是一种基于nutlin靶向 BRD4 的PROTAC，DC50 值为 32 nM，诱导细胞中的 BRD4 降解，抑制癌细胞的增殖。

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

AT1 is a highly selective Brd4 degrader with a modified VHL ligand retained binding to VHL (Kd = 330 nM).

AT6 is a PROTAC targeting on Brd4.

TD-428 is a PROTAC targeting on pan-BET with DC₅₀ of 0.32nM for BRD4, consist of BET inhibitor, JQ1, as a warhead linked to CRBN modulator TD-106 as the E3 ligase ligand.