L-4-Hydroxyisoleucine, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L., acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats.

Gentianine, a natural product isolated and purified from the herbs of Trigonella foenum-graecum L., with potential anti-inflammatory action, might be at least partly based on the suppressed production of TNF-alpha and IL-6.