Neotuberostemonine, a natural product isolated and purified from the roots of Stemona tuberosa, has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruitment and M2 polarization of macrophages and demonstrates antitussive properties in guinea pigs.

Bisdehydroneotuberostemonine is a natural product isolated and purified from the roots of Stemona collinsae.

Protostemotinine is an alkaloid purified from the roots and rhizomes of stemona sessilifolia (Miq.).