SLM6031434 HCl是一种高度选择性的鞘氨醇激酶 2 (SphK2) 抑制剂，能够降低 U937 单核细胞白血病细胞中 1-磷酸鞘氨醇 (S1P) 水平，适用于肾纤维化研究。

ABC294640 markedly alters the ratio of ceramide/S1P consistent with inhibition of SK activity in MDA-MB-231 cells.

PF-543 HCl is a cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.

MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.

SKI II is an inhibitor of non ATP-competitive sphingosine kinase (SphK) with IC50 of 0.5 μM.

K145 HCl is a selective SphK2 inhibitor with an IC50 of 4.30±0.06 μM , while no inhibition of SphK1 at concentrations up to 10 μM.

SphK1&2-IN-1是一种 SphK 抑制剂，靶向 SphK1 和 SphK2。SphK1&2-IN-1 具有热稳定性。

SKI-178 is an in vivo active non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM), which induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines.

Defensamide is an activator of SPHK1, and significantly stimulates CAMP mRNA and protein production in KC.