Zofenopril calcium is sulfhydrylACE inhibitor with antihypertensive activity.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Zofenopril calcium is an antioxidant and acts as an angiotensin-converting enzyme (ACE) inhibitor which has been shown to have beneficial effects in hypertension and heart failure. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat[3]. Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR[4]. Administered orally 15 mg/kg for seven days, Zofenopril has been found effective in promoting nerve regeneration in sciatic nerve crush injury rat model[3]. As individual eliminating organs in dogs received a oral dose of zofenopril calcium (1.5 mg/kg), the gut and liver each had a high intrinsic capability to hydrolyze zofenopril; Extraction ratios (E) values ranged from 45 to 89%[5]. In dog model , Zofenopril was rapidly eliminated after parenteral administration; mean residence time values were 2 min and the elimination half-life values (intraarterial route only) were 9 min[5].
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