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干细胞
Hippo
/ MST / XMU-MP-1

XMU-MP-1 {[allProObj[0].p_purity_real_show]}

货号：A397171

XMU-MP-1是一种可逆且选择性的MST1/2抑制剂，IC50值分别为71.1 nM和38.1 nM。

XMU-MP-1 化学结构 CAS号：2061980-01-4
XMU-MP-1 化学结构
CAS号：2061980-01-4
XMU-MP-1 3D分子结构
CAS号：2061980-01-4
XMU-MP-1 化学结构 CAS号：2061980-01-4
XMU-MP-1 3D分子结构 CAS号：2061980-01-4
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XMU-MP-1 纯度/质量文件 产品仅供科研

货号：A397171 标准纯度： {[allProObj[0].p_purity_real_show]}
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XMU-MP-1 生物活性

描述 The mammalian ste20-like kinases 1/2 (MST1/2) which is a core component in the Hippo pathway in mammals, is related in cell growth, controlling organ size and maintaining organ homeostasis[1]. XMU-MP-1 is a potent and selective inhibitor of MST1/2 with IC50 value of 71.1 nM and 38.1 nM against MST1 and MST2, respectively[2].
XUM-MP-1 was added to a variety of cell lines including RAW264.7, USOS, SW480, SNU-423, RPE1 and HepG2, and the inhibition of hydrogen peroxide (H2O2)–stimulated MOB1 phosphorylation and MST1/2 autophosphorylation started at concentration of 1 and 3 μM for all cell lines measured by immunoblotting assay after incubating with XMU-MP-1 for 3 hours.
In Sprague-Dawley rats, after intraperitoneal administration of 1 mg/kg XMU-MP-1, the maximal phosphorylation inhibition of MOB1 and YAP was achieved between 1.5 and 6 hours in the liver tissue. The wild-type mice were treated with XMU-MP-1 once a day before a two-thirds partial hepatectomy followed by daily treatment for 7 days. The treatment of XMU-MP-1 could enhance liver regeneration and increase the amounts of Ki67-positive cells and YAP-positive cells in the liver, as well as liver/body weight ratio compared with the control group.
作用机制 XMUMP-1 target the ATP-binding site of the kinases MST1/2.

XMU-MP-1 动物研究

Dose Mice: 1 mg/kg - 3 mg/kg[2]
Administration i.p.

XMU-MP-1 参考文献

[1]Pfleger CM. The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease. Curr Top Dev Biol. 2017.

[2]Fan F, He Z, et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med. 2016;8(352):352ra108.

XMU-MP-1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.01mL

2.40mL

1.20mL

24.01mL

4.80mL

2.40mL

XMU-MP-1 技术信息

CAS号2061980-01-4
分子式C17H16N6O3S2
分子量 416.477
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 6 mg/mL(14.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 4 mg/mL clear

PO 0.5% CMC-Na 60 mg/mL suspension

Tags: XMU-MP-1 | 2061980-01-4 | Hippo (MST) | MST1/2 Inhibitor | Stem Cell/Wnt | Hippo (MST) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | XMU-MP-1 纯度/质量文件 | XMU-MP-1 生物活性 | XMU-MP-1 动物研究 | XMU-MP-1 参考文献 | XMU-MP-1 实验方案 | XMU-MP-1 技术信息

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