Neuropeptide Y (NPY), an amino acid, used for various physiological processes for management and treatment of various ailments related to central nervous system, cardiovascular system, respiratory system, gastro-intestinal system and endocrinal system[2].NPY displays a multiplicity of physiological effects that are transmitted by at least six G-protein coupled receptors (GPCRs) named Y(1), Y(2), Y(3), Y(4), Y(5), and y(6)[3]. NPY has also been shown to interact with sigma receptor in vivo and in vitro. There are indications that more subtypes might exist. Ligand binding studies reveal that Y1, Y2 and Y3 receptors are all G-protein coupled[4]. Among them, the Y5 receptor subtype is thought to play a role in meal initiation and the regulation of energy balance. Therefore, an antagonist of the NPY Y5 receptor is considered to have potential as an antiobesity drug[5]. Velneperit is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist[1]. It has been shown to have a significant effect on weight loss in clinical studies, suggesting its potential as a promising antiobesity drugKawanishi, Y.; Takenaka, H.; Hanasaki, K.; Okada, T.WO0137826A1.. In addition, it can ameliorate the glucose metabolism, reduce LDL cholesterol and uric acid levels, lower blood pressure, and improve liver functionKobayashi, Y.; Yoshioka, Y. WO2013002313A1..
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