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氨基甲酸乙酯 /Urethane {[allProObj[0].p_purity_real_show]}

货号:A819809 同义名: 乌拉坦 / Ethyl carbamate;Carbamic acid ethyl ester

Urethane(乌拉坦)常用于肺腺瘤模型的构建,会导致小鼠KrasQ61L或KrasQ61R驱动突变,在广泛靶基因中表现出全基因组A>T或A>G突变,诱导肺肿瘤的发生。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Urethane 化学结构 CAS号:51-79-6
Urethane 化学结构
CAS号:51-79-6
Urethane 3D分子结构
CAS号:51-79-6
Urethane 化学结构 CAS号:51-79-6
Urethane 3D分子结构 CAS号:51-79-6
规格 价格 会员价 库存 数量
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Urethane 纯度/质量文件 产品仅供科研

货号:A819809 标准纯度: {[allProObj[0].p_purity_real_show]}
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Urethane 生物活性

描述 Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a fermentation byproduct found in various food products and is known to inhibit the growth of bacteria, protozoa, sea urchin eggs, and plant tissues in vitro[1].
体内研究

Urethane is utilized in animal research to create tumor models and has historically been used to induce hypnosis and narcosis in mammals, fish, and amphibians. When administered at anesthetic doses (1-1.2 g/kg body weight for rats), urethane is generally safe, causing minimal alterations in blood pressure, aortic blood flow, and blood-gas levels[1].

Additionally, at a dosage of 1g/kg IP (administered intraperitoneally), urethane arrests cell division in the crypt of liberkuhn cells in mice[1].

体外研究

As a clastogen, urethane shows effectiveness in inducing sister chromatid exchanges in various cells and demonstrates variable results with cells in vitro, making it a useful clastogen in mammalian somatic cells in vivo[2].

Urethane 动物研究

Animal study 肺肿瘤模型
动物:hPRDX4 转基因 (Tg) 和非转基因 C57BL/6 小鼠, 雄性,8 周龄。
给药:1 g/kg (在 100 μL 生理盐水中) ,腹腔注射 ,每周一次,持续 16 周或每隔一天一次,持续一周。

Urethane 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00924508 Eczema Not Applicable Terminated(Loss of Funding) - United States, California ... 展开 >> UCSF Psoriasis Skin and Treatment Center San Francisco, California, United States, 94118 收起 <<
NCT02136901 Meniscectomy ... 展开 >>Osteoarthritis 收起 << Not Applicable Active, not recruiting June 2020 Belgium ... 展开 >> AZ Monica Antwerp, Belgium, BE-2018 France Centre Hospitalier de Versailles Le Chesnay CEDEX, France, F 78158 Germany Universitätsklinikum Freiburg Freiburg, Germany, 79106 University Hospital of Munich Munich, Germany, 81377 Universitätklinikum Regensburg Regensburg, Germany, 93042 Israel Ichilov Hospital Tel Aviv, Israel, 64239 Meuhedet HCO Tel-Aviv, Israel, 62038 Assaf Harofeh Medical Center Zerifin, Israel, 70300 Italy Ospedale Sacro Cuore - Don Calabria Negrar, Verona, Italy, 37024 Netherlands Academisch Ziekenhuis Maastricht Maastricht, Netherlands, 66202 Sweden Hallands Sjukhus Kungsbacka Kungsbacka, Halland, Sweden, SE-434 80 收起 <<
NCT01133327 Carotid Artery Disease ... 展开 >> Carotid Stenosis Stroke 收起 << Not Applicable Completed - Belgium ... 展开 >> A.Z. Sint Blasius Dendermonde, East-Flanders, Belgium, 9200 Imelda Ziekenhuis Bonheiden, Belgium, B-9200 CHU Sart Tilman Liege, Belgium, B-400 Germany Königin Elisabeth Herzberge Berlin, Germany, D-10365 Klinikum Dortmund Dortmund, Germany, D-44137 Universitaetsklinikum Heidelberg Heidelberg, Germany, D69120 Park KH Leipzig, Germany, D-04289 Klinikum Neuperlach Munich Munich, Germany, D-81737 Radiologische Universitätklinik Tübingen, Germany, D-72076 Spain Hospital Juan Canalejo La Coruna, Spain, 15174 Complejo Hospitalario de Toledo Toledo, Spain, S-45004 收起 <<

Urethane 参考文献

[1]K J Field, et al. Hazards of urethane (ethyl carbamate): a review of the literature. Lab Anim. 1988 Jul;22(3):255-62.

[2]R E Sotomayor, et al. Mutagenicity, metabolism, and DNA interactions of urethane. Toxicol Ind Health. 1990 Jan;6(1):71-108.

Urethane 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

11.22mL

2.24mL

1.12mL

56.12mL

11.22mL

5.61mL

112.24mL

22.45mL

11.22mL

Urethane 技术信息

CAS号51-79-6
分子式C3H7NO2
分子量 89.093
别名 乌拉坦 ;Ethyl carbamate;Carbamic acid ethyl ester;NSC 746;Ethylurethane
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(1178.54 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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