货号:A630950 同义名: Tyrphostin 1;AG9
Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.
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描述 | Tyrphostin A1 (AG9) is effective in inhibiting CD40L-stimulated IL-12 production in macrophage cultures and preventing the antigen-induced generation of Th1 cells. Its application leads to a dose-dependent reduction of IL-12 p40 levels, achieving maximum inhibition (62.5%) at a 10 μM concentration. Tyrphostin A1 also obstructs the CD40L-induced translocation of NF-κB to the nucleus and diminishes the activation of the IL-12 p40 gene. Therapeutic use of A1 in vivo results in decreased generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice, highlighting its potential for therapeutic applications in autoimmunity [1]. Compared to other tyrphostins, Tyrphostin A1 is a significantly weaker inhibitor of tyrosine kinase (TK), with an IC50 greater than 1250 μM for the epidermal growth factor receptor (EGFR) kinase, indicating its utility in distinguishing TK-mediated effects from non-specific actions of tyrphostins [2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.43mL 1.09mL 0.54mL |
27.15mL 5.43mL 2.71mL |
54.29mL 10.86mL 5.43mL |
CAS号 | 2826-26-8 |
分子式 | C11H8N2O |
分子量 | 184.194 |
别名 | Tyrphostin 1;AG9 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(570.05 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |