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产品名称 | diphenolase ↓ ↑ | monophenolase ↓ ↑ | tyrosinase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hexylresorcinol |
+++
diphenolase, IC50: 0.85 μM |
++
monophenolase, IC50: 1.24 μM |
+++
monophenolase, IC50: 0.85 μM diphenolase, IC50: 0.85 μM |
99%+ | |||||||||||||||
Aloin | ✔ | 98% | |||||||||||||||||
Arbutin |
+
tyrosinase, IC50: 1.09 mM |
99%+ | |||||||||||||||||
Monobenzone | ✔ | 98% | |||||||||||||||||
Deoxyarbutin |
++++
tyrosinase, IC50: 50 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Tyrosinase-IN-11 exhibits potent inhibition against tyrosinase, with IC50 values of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. It demonstrates significant antioxidant activity and low cytotoxicity, rendering it valuable for skin hyperpigmentation research[1]. |
体内研究 | Upon topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks at concentrations of 0.5 and 1 mM, Tyrosinase-IN-11 demonstrates potent antimelanogenesis ability in a guinea pig model in vivo[1]. |
体外研究 | Tyrosinase-IN-11 (0.1-2 μM; 72 h) reduces protein levels of both TYR and MiTF in a dose-dependent manner[1]. Tyrosinase-IN-11, at a concentration of 50 μM, exhibits slight cytotoxicity in human malignant melanoma cells A375 and B16F10 cells[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.65mL 0.73mL 0.36mL |
18.23mL 3.65mL 1.82mL |
36.46mL 7.29mL 3.65mL |
CAS号 | 240797-64-2 |
分子式 | C15H14O5 |
分子量 | 274.269 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 | |
动物实验配方 |