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首页 / 动物造模剂 / 循环系统疾病模型 / 心脏疾病相关模型 / Trimethylamine N-oxide dihydrate

二水氧化三甲胺 /Trimethylamine N-oxide dihydrate {[allProObj[0].p_purity_real_show]}

货号：A690734 同义名： 三甲胺 N-氧化物二水合物

Trimethylamine N-oxide dihydrate is an endogenous metabolite.

Trimethylamine N-oxide dihydrate 化学结构 CAS号：62637-93-8
Trimethylamine N-oxide dihydrate 化学结构
CAS号：62637-93-8
Trimethylamine N-oxide dihydrate 3D分子结构
CAS号：62637-93-8
Trimethylamine N-oxide dihydrate 化学结构 CAS号：62637-93-8
Trimethylamine N-oxide dihydrate 3D分子结构 CAS号：62637-93-8
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Trimethylamine N-oxide dihydrate 纯度/质量文件 产品仅供科研

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Trimethylamine N-oxide dihydrate 生物活性

描述 Trimethylamine N-oxide dihydrate is an endogenous metabolite. Urine was the major route of excretion of radioactivity (95% dose in 0-24 h) following the oral, intravenous or intraperitoneal administration of [14C]-trimethylamine N-oxide dihydrate (1 mmol/kg body wt) to the adult male Wistar rat. A further 3-4% was voided in the urine during 24-72 h. Only fractional amounts were detected in the faeces, or were retained within tissues 3 days after administration. The only radioactive compounds identified in the urine were trimethylamine N-oxide and dimethylamine. Incubation of trimethylamine N-oxide with gut contents (especially colon and rectum) led to the formation of dimethylamine[1]. The restoration effects of TMAO (trimethylamine N-oxide dihydrate) and nitrate on LT (Heat-labile enterotoxin) secretion could be inhibited by amytal or ΔtorCAD and ΔnarG E. coli strains, indicating that LT secretion under anaerobic conditions was dependent on the integrity of the respiratory chain[2].

Trimethylamine N-oxide dihydrate 参考文献

[1]Mitchell SC, Zhang AQ, Noblet JM, Gillespie S, Jones N, Smith RL. Metabolic disposition of [14C]-trimethylamine N-oxide in rat: variation with dose and route of administration. Xenobiotica. 1997;27(11):1187‐1197

[2]Lu X, Fu E, Xie Y, Jin F. Electron Acceptors Induce Secretion of Enterotoxigenic Escherichia coli Heat-Labile Enterotoxin under Anaerobic Conditions through Promotion of GspD Assembly. Infect Immun. 2016;84(10):2748‐2757.

Trimethylamine N-oxide dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

9.00mL

1.80mL

0.90mL

44.99mL

9.00mL

4.50mL

89.98mL

18.00mL

9.00mL

Trimethylamine N-oxide dihydrate 技术信息

CAS号62637-93-8
分子式C3H13NO3
分子量 111.14
别名 三甲胺 N-氧化物二水合物
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

H2O: 100 mg/mL(899.76 mM)，配合低频超声助溶
动物实验配方

Tags: Trimethylamine N-oxide dihydrate | 62637-93-8 | ROS/NLRP3 Inflammasome Activator | Induced Disease Models Products | Immunology/Inflammation | NF-κB | Stem Cell/Wnt | TGF-beta/Smad | Metabolic Enzyme/Protease | Cardiovascular System Disease Models | NOD-like Receptor (NLR) | Reactive Oxygen Species | TGF-beta/Smad | Endogenous Metabolite | Heart Disease Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Trimethylamine N-oxide dihydrate 纯度/质量文件 | Trimethylamine N-oxide dihydrate 生物活性 | Trimethylamine N-oxide dihydrate 参考文献 | Trimethylamine N-oxide dihydrate 实验方案 | Trimethylamine N-oxide dihydrate 技术信息

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