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妥布霉素 /Tobramycin {[allProObj[0].p_purity_real_show]}

货号:A976001 同义名: 托普霉素 / Nebramycin Factor 6;Deoxykanamycin B

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Tobramycin 化学结构 CAS号:32986-56-4
Tobramycin 化学结构
CAS号:32986-56-4
Tobramycin 3D分子结构
CAS号:32986-56-4
Tobramycin 化学结构 CAS号:32986-56-4
Tobramycin 3D分子结构 CAS号:32986-56-4
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Tobramycin 纯度/质量文件 产品仅供科研

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Tobramycin 生物活性

描述 Tobramycin is a new aminoglycoside antibiotic with a broad antibacterial spectrum in vitro, and pharmacokinetic properties similar to those for gentamicin. Like other aminoglycoside antibiotics, tobramycin is active in vitro in low concentrations against Staphylococcus aureus. The sensitivity of P. aeruginosa to tobramycin is influenced by the magnesium, and calcium content of the culture media whilst that of all species is reduced by sodium ions[2]. Aerosolized tobramycin 100 mg/ml solution delivered higher lung dose compared to tobramycin 40 mg/ml solution[3]. When tilmicosin is used to treat clinical outbreaks of M. gallisepticum in broilers, a dosing scheme of 20 mg tilmicosin/kg BW (body weight) for five successive days seems to be the most recommended scheme[4].

Tobramycin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02958514 Dry Eye Syndrome Not Applicable Unknown March 2017 -
NCT01319253 - Completed - United States, Indiana ... 展开 >> Indiana University Indianapolis, Indiana, United States, 46202 收起 <<
NCT02334384 Furunculosis Phase 1 Phase 2 Completed - United States, Virginia ... 展开 >> Sentara Norfolk General Hospital Norfolk, Virginia, United States, 23507 收起 <<

Tobramycin 参考文献

[1]Loose M, Naber KG, et al. Urinary concentration and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption. Int J Antimicrob Agents. 2017 Nov 17. pii: S0924-8579(17)30396-5.

[2]Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use. Drugs. 1976;12(3):166–200

[3]Brogden RN, Pinder RM, Sawyer PR, Speight TM, Avery GS. Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use. Drugs. 1976;12(3):166–200

[4]Garmyn A, Vereecken M, De Gussem K, Depondt W, Haesebrouck F, Martel A. Efficacy of Tylosin and Tilmicosin Against Experimental Mycoplasma gallisepticum Infection in Chickens. Avian Dis. 2019;63(2):359–365

Tobramycin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.69mL

2.14mL

1.07mL

21.39mL

4.28mL

2.14mL

Tobramycin 技术信息

CAS号32986-56-4
分子式C18H37N5O9
分子量 467.514
别名 托普霉素 ;Nebramycin Factor 6;Deoxykanamycin B;NSC 180514;Gernebcin;Distobram
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 2 mg/mL(4.28 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(213.9 mM)

动物实验配方
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