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盐酸替诺立定 /Tinoridine HCl {[allProObj[0].p_purity_real_show]}

货号：A388367 同义名： Y-3642 HCl;Y-3642 hydrochloride

Tinoridine HCl is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.

Tinoridine HCl 化学结构 CAS号：25913-34-2
Tinoridine HCl 化学结构
CAS号：25913-34-2
Tinoridine HCl 3D分子结构
CAS号：25913-34-2
Tinoridine HCl 化学结构 CAS号：25913-34-2
Tinoridine HCl 3D分子结构 CAS号：25913-34-2
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Tinoridine HCl 纯度/质量文件 产品仅供科研

货号：A388367 标准纯度： {[allProObj[0].p_purity_real_show]}
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Tinoridine HCl 生物活性

描述 Active oxygen species have been implicated in a variety of pathophysiological conditions, such as inflammation, aging, hepatotoxicity and ischemic brain and myocardium damage. Tinoridine, a non-steroidal anti-inflammatory drug, inhibits the lipid peroxidation in rat liver microsomes and mitochondria. The anti-peroxidative activity of tinoridine has been suggested to contribute to its membrane stabilizing activity demonstrated on various biomembranes. Tinoridine reduced a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1∶2, indicating its free radical scavenging ability. Tinoridine inhibited the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe2+, in which hydroxyl radical (•OH) is formed. These results indicate that tinoridine is able to scavenge •OH and the main active oxygen species responsible for the lipid peroxidation is •OH[1]. In addition, the administration of tinoridine (100 mg/kg) to rats prevented the CCl4-induced hepatotoxicity, in which the lipid peroxidation in microsomes caused by CC14 is suggested to have a decisive role[2].

Tinoridine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01224756 Pain Inflamma... 展开 >>tion 收起 << Phase 4 Completed - Indonesia ... 展开 >> Semarang, Central Java, Indonesia Jakarta, DKI Jakarta, Indonesia Surabaya, East Java, Indonesia Bandung, West Java, Indonesia 收起 <<

Tinoridine HCl 参考文献

[1]Hydroxyl radical scavenging action of tinoridine

[2]Yasuda H, Izumi N, Shimada O, Kobayakawa T, Nakanishi M. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1980;52(3):407‐413

Tinoridine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.17mL

2.83mL

1.42mL

28.34mL

5.67mL

2.83mL

Tinoridine HCl 技术信息

CAS号25913-34-2
分子式C17H21ClN2O2S
分子量 352.879
别名 Y-3642 HCl;Y-3642 hydrochloride;Tinoridine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 16 mg/mL(45.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(7.08 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方

Tags: Tinoridine | 25913-34-2 | Y-3642 | Y3642 | Y 3642 | Glutathione Peroxidase Activator | Apoptosis | Metabolic Enzyme/Protease | Glutathione Peroxidase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tinoridine HCl 纯度/质量文件 | Tinoridine HCl 生物活性 | Tinoridine HCl 临床数据 | Tinoridine HCl 参考文献 | Tinoridine HCl 实验方案 | Tinoridine HCl 技术信息

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