货号:A318271 同义名: NA-1;Tat-NR2Bct
Tat-NR2B9c is a PSD95 inhibitor with EC50 of 7 nM, also inhibit p38.
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描述 | Postsynaptic density protein-95 (PSD-95)/Discs-large/ZO-1 (PDZ) domains play an essential role in the regulation of intracellular signaling involved in neuronal disease and cancer. Tat-NR2B9c is a 20-mer peptide consisting of nine C-terminal amino acids of the NMDA NR2B subunit. It inhibits PSD-95 domain 1 and PSD-95 domain 2 with EC50 values of 670 nM and 6.7 nM, respectively. The IC50 values for Tat-NR2B9c inhibiting the interactions between NMDAR2A, NMDAR2B, NMDAR2C and PSD-95 are 0.5, 8, and 0.75μm, respectively. Tat-NR2B9c also inhibits the interaction between neuronal nitric oxide synthase and PSD-95 with an IC50 value of 0.2μm[3]. In NMDA-treated neuronal cultures, Tat-NR2B9c at 0.5µM suppressed NMDA-induced superoxide production by 75%. The NMDA-type glutamate receptor-triggered NOX2 activation and DNA damage were also prevented by Tat-NR2B9c at 0.5µM[4]. In mice subjected to temporary middle cerebral artery occlusion (tMCAO) for 30 and 60 min, treatment with 10nmol/g Tat-NR2B9c significantly decreased infarct volumes by 24.5% and 26.0%, respectively[5]. |
Dose | Rat: 1.12 mg/kg[3] (i.v.) |
Administration | i.v. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.40mL 0.08mL 0.04mL |
1.99mL 0.40mL 0.20mL |
3.97mL 0.79mL 0.40mL |
CAS号 | 500992-11-0 |
分子式 | C105H188N42O30 |
分子量 | 2518.88 |
别名 | NA-1;Tat-NR2Bct |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
H2O: 100 mg/mL(39.7 mM),配合低频超声助溶 |
动物实验配方 |