A single intraperitoneal injection of TDI-011536 at 200 mg/kg provides sustained Lats inhibition for over 4 hours in the liver, heart, and skin. Additionally, it decreases the levels of pYap in all three organs for at least 4 hours post-injection^[1].

TDI-011536, administered intraperitoneally at 100 mg/kg once daily for 2 or 3 days, demonstrates a proliferative effect on cardiomyocytes^[1].

At a concentration of 3 µM for 24 hours, TDI-011536 reduces Yap phosphorylation, while at the same concentration for 5 days, it induces the proliferation of Müller glia in human retinal organoids^[1].