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/ Sulfapyridine

磺胺吡啶 /Sulfapyridine {[allProObj[0].p_purity_real_show]}

货号：A313387 同义名： NSC 41791;NSC 4753

Sulfapyridine is a sulfonamide antibiotic mostly used in treating rheumatoid arthritis and certain skin diseases with potentially toxicity.

Sulfapyridine 化学结构 CAS号：144-83-2
Sulfapyridine 化学结构
CAS号：144-83-2
Sulfapyridine 3D分子结构
CAS号：144-83-2
Sulfapyridine 化学结构 CAS号：144-83-2
Sulfapyridine 3D分子结构 CAS号：144-83-2
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Sulfapyridine 纯度/质量文件 产品仅供科研

货号：A313387 标准纯度： {[allProObj[0].p_purity_real_show]}
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Sulfapyridine 生物活性

描述 Sulfasalazine was the first aminosalicylate to be used for induction and maintenance therapy of ulcerative colitis (UC)[3]. Sulfasalazine is a potent inhibitor of superoxide production and granule enzyme release by stimulated neutrophils, and modulation of these responses may contribute to its anti-inflammatory properties. The inhibitory effects of sulfasalazine on superoxide production, degranulation and neutrophil-mediated collagen degradation were closely mimicked by olsalazine[4]. Sulfasalazine and sulfapyridine but not 5-aminosalicylate inhibit spontaneous cytotoxicity mediated by human natural killer (NK) cells[5].

Sulfapyridine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01596777 Intestinal Obstruction Phase 1 Completed - Germany ... 展开 >> Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald Greifswald, Mecklenburg-Vorpommern, Germany 收起 <<
NCT00637780 Arthritis, Juvenile Rheumatoid Phase 4 Terminated(Study terminated on... 展开 >> 13 April 2016 for business reasons. No safety and/or efficacy concerns contributed to the termination of the study) 收起 << - United States, Ohio ... 展开 >> University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 Mexico Private Office Guadalajara, Jalisco, Mexico, 44650 收起 <<
NCT01596764 Intestinal Obstruction Phase 1 Completed - Germany ... 展开 >> Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald Greifswald, Mecklenburg-Vorpommern, Germany 收起 <<

Sulfapyridine 参考文献

[1]Marzano IM, Franco MS, et al. Crystal structure, antibacterial and cytotoxic activities of a new complex of bismuth(III) with sulfapyridine. Molecules. 2013 Jan 24;18(2):1464-76.

[2]Hanauer SB. Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis. Aliment Pharmacol Ther. 2006 Oct;24 Suppl 3:37-40.

[3]Hanauer SB. Review article: high-dose aminosalicylates to induce and maintain remissions in ulcerative colitis. Aliment Pharmacol Ther. 2006;24 Suppl 3:37–40.

[4]Neal TM, Winterbourn CC, Vissers MC. Inhibition of neutrophil degranulation and superoxide production by sulfasalazine. Comparison with 5-aminosalicylic acid, sulfapyridine and olsalazine. Biochem Pharmacol. 1987;36(17):2765–2768.

[5]Shanahan F, Niederlehner A, MacDermott RP, Stenson WF, Kane MG, Targan S. Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes. Immunopharmacology. 1986;11(2):111–118.

Sulfapyridine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.11mL

8.02mL

4.01mL

Sulfapyridine 技术信息

CAS号144-83-2
分子式C11H11N3O2S
分子量 249.289
别名 NSC 41791;NSC 4753;Pyriamid;Plurazol;A 499;Sulphapyridine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 60 mg/mL(240.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Sulfapyridine | NSC 41791;NSC 4753;Pyriamid;Plurazol;A 499;Sulphapyridine | Sulfonamide | Antibacterial | AmBeed-信号通路专用抑制剂 | Sulfapyridine 纯度/质量文件 | Sulfapyridine 生物活性 | Sulfapyridine 临床数据 | Sulfapyridine 参考文献 | Sulfapyridine 实验方案 | Sulfapyridine 技术信息

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