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/ Spectinomycin 2HCl pentahydrate

Spectinomycin 2HCl pentahydrate {[allProObj[0].p_purity_real_show]}

货号：A206958 同义名： Spectinomycin hydrochloride hydrate; Spectinomycin (hydrochloride hydrate)

Spectinomycin dihydrochloride pentahydrate用于治疗非洲锥虫病、利什曼病、巴贝虫病，并用于预防和治疗免疫功能差患者的肺孢子虫肺炎 (PCP)。

Spectinomycin 2HCl pentahydrate 化学结构 CAS号：22189-32-8
Spectinomycin 2HCl pentahydrate 化学结构
CAS号：22189-32-8
Spectinomycin 2HCl pentahydrate 3D分子结构
CAS号：22189-32-8
Spectinomycin 2HCl pentahydrate 化学结构 CAS号：22189-32-8
Spectinomycin 2HCl pentahydrate 3D分子结构 CAS号：22189-32-8
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Spectinomycin 2HCl pentahydrate 纯度/质量文件 产品仅供科研

货号：A206958 标准纯度： {[allProObj[0].p_purity_real_show]}
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Spectinomycin 2HCl pentahydrate 生物活性

描述 Spectinomycin (Dihydrochloride Pentahydrate) is a broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of uncomplicated gonorrhea. It is a good alternative drug in the treatment of penicillin-allergic patients[3]. Aminomethyl spectinomycins are active against Gram-negative and Gram-positive bacterial pathogens. Aminomethyl spectinomycins are promising new candidates for development of therapeutics against biodefense bacterial agents[4]. Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. However, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides[5]. The kinetic analysis demonstrated that spectinomycin acts as a mixed noncompetitive inhibitor for the td (T4 thymidylate synthase gene) intron RNA with a K(i) of 7.2 mM. Increasing the spectinomycin concentration raised the K(m) values with the corresponding decrease of V(max) and k(cat) values[6].

Spectinomycin 2HCl pentahydrate 参考文献

[1]Willcox RR. Spectinomycin dihydrochloride in the treatment of gonorrhoea in males. Br J Clin Pract. 1975 Feb;29(2):34-36.

[2]Porter IA, Wood WJ. Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae. Br J Vener Dis. 1974 Aug;50(4):289-90.

[3]Holloway WJ. Spectinomycin. Med Clin North Am. 1982;66(1):169–173

[4]Scarff JM, Waidyarachchi SL, Meyer CJ, et al. Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens. J Antibiot (Tokyo). 2019;72(9):693–701

[5]Davies J, Anderson P, Davis BD. Inhibition of protein synthesis by spectinomycin. Science. 1965;149(3688):1096–1098

[6]Park IK, Kim JY, Lim EH, Shin S. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. Biochem Biophys Res Commun. 2000;269(2):574–579

Spectinomycin 2HCl pentahydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.09mL

2.02mL

1.01mL

20.19mL

4.04mL

2.02mL

Spectinomycin 2HCl pentahydrate 技术信息

CAS号22189-32-8
分子式C14H36Cl2N2O12
分子量 495.35
SMILES Code CN[C@H]([C@@]1([C@@]2(O[C@@]([H])([C@]3(O1)O)O[C@@H](CC3=O)C)[H])[H])[C@@H](O)[C@H]([C@@H]2O)NC.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl.Cl
别名 Spectinomycin hydrochloride hydrate; Spectinomycin (hydrochloride hydrate); Trobicin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C
溶解方案

H2O: 60 mg/mL(121.13 mM)，配合低频超声助溶

Tags: Spectinomycin dihydrochloride pentahydrate | Spectinomycin hydrochloride hydrate;Spectinomycin (hydrochloride hydrate);Trobicin | Aminoglycoside | Antibacterial | AmBeed-信号通路专用抑制剂 | Spectinomycin 2HCl pentahydrate 纯度/质量文件 | Spectinomycin 2HCl pentahydrate 生物活性 | Spectinomycin 2HCl pentahydrate 参考文献 | Spectinomycin 2HCl pentahydrate 实验方案 | Spectinomycin 2HCl pentahydrate 技术信息

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