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沙拉沙星盐酸盐 /Sarafloxacin HCl {[allProObj[0].p_purity_real_show]}

货号:A129788 同义名: 盐酸沙拉沙星 / A-56620 hydrochloride;Sarafloxacin (hydrochloride)

Sarafloxacin HCl is a veterinary fluoroquinolone antibiotic which can bacterial DNA gyrase

Sarafloxacin HCl 化学结构 CAS号:91296-87-6
Sarafloxacin HCl 化学结构
CAS号:91296-87-6
Sarafloxacin HCl 3D分子结构
CAS号:91296-87-6
Sarafloxacin HCl 化学结构 CAS号:91296-87-6
Sarafloxacin HCl 3D分子结构 CAS号:91296-87-6
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Sarafloxacin HCl 纯度/质量文件 产品仅供科研

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Sarafloxacin HCl 生物活性

描述 Sarafloxacin Hydrochloride is a quinolone antibiotic drug. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model[3]. Based on a minimum inhibitory concentration (MIC) of 0.00625 to 0.045 μg/mL for susceptible strains, sarafloxacin p.o. administration at a dose 10 mg/kg could be efficacious against common pathogenic bacteria of fish[4].

Sarafloxacin HCl 参考文献

[1]Liu YZ, Zhao GX, et al. Production of the broad specific monoclonal antibody against sarafloxacin for rapid immunoscreening of 12 fluoroquinolones in meat. J Environ Sci Health B. 2013;48(2):139-46.

[2]McConville ML, Dijkstra JW, et al. Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q. 1995 Mar;17(1):1-5.

[3]McConville ML, Dijkstra JW, Stamm JM, van Saene JJ, Nouws JF. Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q. 1995 Mar;17(1):1-5.

[4]Fang X, Zhou J, Liu X. Pharmacokinetics of sarafloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio. Fish Physiol Biochem. 2016 Feb;42(1):335-41.

Sarafloxacin HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.85mL

2.37mL

1.19mL

23.71mL

4.74mL

2.37mL

Sarafloxacin HCl 技术信息

CAS号91296-87-6
分子式C20H18ClF2N3O3
分子量 421.825
别名 盐酸沙拉沙星 ;A-56620 hydrochloride;Sarafloxacin (hydrochloride);A-56620;A-56620 HCl;Sarafloxacin hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 7 mg/mL(16.59 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.37 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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