Rilpivirine is a diarylpyrimidine derivative that functions as a non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infection. It demonstrated more pronounced activity against wild-type HIV-1 (EC50 = 0.4 nM) and all single and double mutants as compared to other NNRTIs, such as nevirapine, efavirenz, TMC120, and TMC125. Rilpivirine at 1 μM showed no sign of virus breakthrough for wild-type HIV-1 within 30 days. Compared to the E-isomer of rilpivirine, the Z-isomer exhibited relatively high potency against wild-type HIV-1 with an EC50 value of 0.6 nM, but showed five times less activity against single and double mutants. Rilpivirine inhibited 81% of the 1200 recombinant clinical isolates collected from HIV-infected patients with an EC50 value less than 1 nM. The IC50 values of rilpivirine for the inhibition of CYP450 isoforms 3A4, 2C9, and 2D6 were 4.6, 5.0, and >10 μM, respectively. The pharmacokinetic studies after the i.v. administration of rilpivirine showed that the elimination half-life was 4.4 h in rat and 31h in dog. The exposure (AUCinf) were 3.1 μg h/mL (i.v. dose of 4 mg/kg) in rat, 8.7 μg h/mL (i.v. dose of 1.25 mg/kg) in dog, 1.4 μg h/mL (i.v. dose of 1.25 mg/kg) in monkey, and 44 μg h/mL (i.v. dose of 1.25 mg/kg) in rabbit.
作用机制
Rilpivirine is a NNRTI that shows potent activity against wild-type and mutant HIV-1 strains. The improved activity in comparison to other NNRTIs may involve a specific interaction of the cyano group in wing I with the indole ring of Trp229.
Rilpivirine 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
human MT4 cells
Function assay
72 h
Antiviral activity against NNRTI-resistant HIV1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as inhibition of viral replication after 72 hrs by HeLa-CD4-LTR-beta-gal assay, EC50=0.0037 μM
23137340
human PBMC cells
Function assay
Antiviral activity against Human immunodeficiency virus 1 subtype D isolate 92UG001 infected in human PBMC cells by cell based assay, EC50=0.00026 μM
19933797
human TZM-bl cells
Cytotoxicity assay
4 days
Cytotoxicity against human TZM-bl cells after 4 days by XTT assay, CC50=19.4 μM
22856541
MT2 cells
Cytotoxicity assay
Cytotoxicity in human MT2 cells assessed as inhibition of cell growth, CC50=8 μM
Antiviral activity against NNRTI-resistant HIV1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as inhibition of viral replication after 72 hrs by HeLa-CD4-LTR-beta-gal assay, EC50=0.0037 μM
23137340
human PBMC cells
Function assay
Antiviral activity against Human immunodeficiency virus 1 subtype D isolate 92UG001 infected in human PBMC cells by cell based assay, EC50=0.00026 μM
19933797
human TZM-bl cells
Cytotoxicity assay
4 days
Cytotoxicity against human TZM-bl cells after 4 days by XTT assay, CC50=19.4 μM
22856541
MT2 cells
Cytotoxicity assay
Cytotoxicity in human MT2 cells assessed as inhibition of cell growth, CC50=8 μM
23298809
MT2 cells
Function assay
Antiviral activity against Human immunodeficiency virus 1 NL4.3 reverse transcriptase K103N and Y181C double mutant infected in human MT2 cells assessed as inhibition of viral infection, EC50=0.002 μM
22081993
MT4 cells
Function assay
Antiviral activity against wild type HIV1 LAI infected in MT4 cells by EGFP based replication assay, EC50=0.001 μM
17223230
MT4 cells
Cytotoxicity assay
3 days
Cytotoxicity against human MT4 cells after 3 days by EGFP based replication assay, CC50=2 μM
France
... 展开 >> Hôpital Meynard
Fort-de-france, Martinique, France, 97261
Hôpital Avicenne
Bobigny, France, 93000
CHU Côte de Nacre
Caen, France, 14033
Centre Hospitalier Sud Francilien
Corbeil Essonnes, France, 91100
Hôpital Le Bocage
Dijon, France, 21079
Hôpital Raymond Poincaré
Garches, France, 92380
Hôpital Bicêtre
Kremlin Bicetre, France, 94275
Hôpital Gui de Chauliac
Montpellier, France, 34295
Hôpital Saint-Antoine
Paris, France, 75012
Hôpital Pitié-Salpêtrière
Paris, France, 75013
Hôpital Européen Georges Pompidou
Paris, France, 75015
Hôpital Necker
Paris, France, 75015
Hôpital Bichat
Paris, France, 75018
Hôpital Tenon
Paris, France, 75020
Hôpital Foch
Suresnes, France, 92151
Hôpital Purpan
Toulouse, France, 31059
Hôpital Bretonneau
Tours, France, 37044 收起 <<
United States, California
... 展开 >>
Mills Clinical Research
Los Angeles, California, United States, 90069
UCSD Antiviral Research Center (AVRC)
San Diego, California, United States, 92103
United States, Florida
Midway Immunology & Research Center
Fort Pierce, Florida, United States, 34982
Orlando Immunology Center Recruiting
Orlando, Florida, United States, 32803
United States, Ohio
Ohio State University Infectious Diseases Research
Columbus, Ohio, United States, 43210
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Texas
Central Texas Clinical Research
Austin, Texas, United States, 78705
United States, Washington
Peter Shalit, MD
Seattle, Washington, United States, 98104 收起 <<
Canada, Ontario
... 展开 >>
The Ottawa Hospital, General Campus
Ottawa, Ontario, Canada
Canada, Quebec
The Research Institute of the McGill University Health Centre
Montreal, Quebec, Canada, H4A 3J1 收起 <<
United States, California
... 展开 >>
University of Southern California CRS
Not yet recruiting
Los Angeles, California, United States, 90033-1079
Contact: Luis M. Mendez 323-343-8283 lmendez@usc.edu
UCLA CARE Center CRS
Not yet recruiting
Los Angeles, California, United States, 90035
Contact: Arezou S. Akha, M.D., M.S. 310-557-3798 asadighi@mednet.ucla.edu
UCSD Antiviral Research Center CRS
Not yet recruiting
San Diego, California, United States, 92103
Contact: Jill Kunkel, R.N. 619-543-8080 jkunkel@ucsd.edu
Ucsf Hiv/Aids Crs
Not yet recruiting
San Francisco, California, United States, 94110
Contact: Jay Dwyer 415-476-4082 ext 353 Jay.Dwyer@ucsf.edu
Harbor-UCLA CRS
Not yet recruiting
Torrance, California, United States, 90502
Contact: Mario Guerrero 424-201-3000 ext 7318 mguerrero@labiomed.org
United States, Colorado
University of Colorado Hospital CRS
Not yet recruiting
Aurora, Colorado, United States, 80045
Contact: Suzanne Fiorillo, M.S.P.H. 303-724-5931 suzanne.fiorillo@ucdenver.edu
United States, Georgia
The Ponce de Leon Center CRS
Not yet recruiting
Atlanta, Georgia, United States, 30308-2012
Contact: Ericka Patrick, M.S.N. 404-616-6313 erpatri@emory.edu
United States, Massachusetts
Massachusetts General Hospital CRS (MGH CRS)
Not yet recruiting
Boston, Massachusetts, United States, 02114
Contact: Theresa Flynn, R.N., M.S.N., A.N.P., B.S.N. 617-724-0072 tflynn@partners.org
Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS
Not yet recruiting
Boston, Massachusetts, United States, 02115
Contact: Cheryl E. Keenan, R.N. 617-732-5635 CKeenan@BWH.Harvard.edu
United States, Missouri
Washington University Therapeutics (WT) CRS
Not yet recruiting
Saint Louis, Missouri, United States, 63110-1010
Contact: Michael K. Klebert 314-747-1098 mklebert@dom.wustl.edu
United States, New York
Weill Cornell Chelsea CRS
Not yet recruiting
New York, New York, United States, 10010
Contact: Todd Stroberg, R.N., B.S.N. 212-746-7198 tstrober@med.cornell.edu
Columbia P&S CRS
Not yet recruiting
New York, New York, United States, 10032-3732
Contact: Steven Palmer, P.A. -C 212-342-2958 sp500@cumc.columbia.edu
Weill Cornell Uptown CRS
Not yet recruiting
New York, New York, United States, 10065
Contact: Rebecca Fry, M.S.N., FNP 212-746-4166 ref2007@med.cornell.edu
United States, North Carolina
Chapel Hill CRS
Not yet recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Becky Straub, B.S.N., M.P.H. 919-843-9975 bstraub@med.unc.edu
Greensboro CRS
Not yet recruiting
Greensboro, North Carolina, United States, 27401
Contact: Kim Epperson, R.N., B.S.N., CRC 336-832-3262 kim.epperson@conehealth.com
United States, Ohio
Cincinnati Clinical Research Site
Not yet recruiting
Cincinnati, Ohio, United States, 45219
Contact: Sharon Kohrs, R.N., B.S.N. 513-584-6383 kohrssd@ucmail.uc.edu
Case Clinical Research Site
Not yet recruiting
Cleveland, Ohio, United States, 44106
Contact: Jane Baum, R.N. 216-844-2546 jb@clevelandactu.org
United States, Pennsylvania
Penn Therapeutics, CRS
Not yet recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Eileen B. Donaghy, C.R.N.P. 215-349-8092 eileen.donaghy2@uphs.upenn.edu
United States, Rhode Island
The Miriam Hospital Clinical Research Site (TMH CRS) CRS
Not yet recruiting
Providence, Rhode Island, United States, 02906
Contact: Pamela Poethke, R.N. 401-793-4971 ppoethke@lifespan.org
United States, Tennessee
Vanderbilt Therapeutics (VT) CRS
Not yet recruiting
Nashville, Tennessee, United States, 37204
Contact: Beverly O. Woodward, M.S.N., R.N. 615-936-8516 beverly.o.woodward@vanderbilt.edu
United States, Washington
University of Washington AIDS CRS
Not yet recruiting
Seattle, Washington, United States, 98104-9929
Contact: Christine Jonsson 206-744-8886 cjonsson@u.washington.edu
Puerto Rico
Puerto Rico AIDS Clinical Trials Unit CRS
Not yet recruiting
San Juan, Puerto Rico, 00935
Contact: Sylvia I. Davila Nieves, M.Sc. 787-767-9192 sylvia.davila1@upr.edu
San Juan City Hosp. PR NICHD CRS
Not yet recruiting
San Juan, Puerto Rico, 00936
Contact: Lizbeth Fabregas-Troche, B.S., M.S. 787-764-3083 lfabregas@sanjuanciudadpatria.com 收起 <<
United States, Florida
... 展开 >>
GSK Investigational Site
Not yet recruiting
Fort Lauderdale, Florida, United States, 33316
Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com
Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com
United States, Texas
GSK Investigational Site
Not yet recruiting
Dallas, Texas, United States, 75246
Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com
Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com 收起 <<
Impaired Cognition
... 展开 >> Depression/Anxiety
Poor Quality Sleep
Quality of Life
HIV-1 Infection 收起 <<
Phase 4
Completed
-
Italy
... 展开 >> Clinic of Infectious Diseases, AO San Gerardo
Monza, MB, Italy, 20900
Spedali Civili - University of Brescia
Brescia, Italy
Clinica di Malattie Infettive, Ospedale San Martino
Genova, Italy
AO San Paolo - University of Milan
Milan, Italy
Ospedale Amedeo di Savoia - University of Turin
Torino, Italy 收起 <<
Infection, Human Immunodeficie... 展开 >>ncy Virus 收起 <<
Phase 1
Completed
-
United States, Florida
... 展开 >>
GSK Investigational Site
Daytona Beach, Florida, United States, 32117
United States, Kansas
GSK Investigational Site
Overland Park, Kansas, United States, 66211 收起 <<
United States, Alabama
... 展开 >>
31788 Alabama CRS
Birmingham, Alabama, United States, 35294
United States, California
801 University of California, San Francisco HIV/AIDS CRS
San Francisco, California, United States, 94110
United States, District of Columbia
Whitman Walker Health CRS (31791)
Washington, District of Columbia, United States, 20009
United States, Georgia
The Ponce de Leon Ctr. CRS (5802)
Atlanta, Georgia, United States, 30308
United States, Illinois
Northwestern University CRS (2701)
Chicago, Illinois, United States, 60611
Rush Univ. Med. Ctr. ACTG CRS (2702)
Chicago, Illinois, United States, 60612
United States, Maryland
IHV Baltimore Treatment CRS (4651)
Baltimore, Maryland, United States, 21201
United States, Massachusetts
Massachusetts General Hospital ACTG CRS (101)
Boston, Massachusetts, United States, 02114
Brigham and Women's Hosp. ACTG CRS (107)
Boston, Massachusetts, United States, 02115
United States, New York
Bronx-Lebanon Hosp. Ctr. CRS (31469)
Bronx, New York, United States, 10457
University of Rochester Adult HIV Therapeutic Strategies Network CRS (31787)
Rochester, New York, United States, 14642
United States, North Carolina
Unc Aids Crs (3201)
Chapel Hill, North Carolina, United States, 27516
Moses H. Cone Memorial Hospital CRS (3203)
Greensboro, North Carolina, United States, 27401
United States, Ohio
University of Cincinnati CRS (2401)
Cincinnati, Ohio, United States, 45267
Metro Health CRS (2503)
Cleveland, Ohio, United States, 44109
United States, Pennsylvania
Hosp. of the Univ. of Pennsylvania CRS (6201)
Philadelphia, Pennsylvania, United States, 19104
Pitt CRS (1001)
Pittsburgh, Pennsylvania, United States, 15213
United States, Rhode Island
The Miriam Hosp. ACTG CRS (2951)
Providence, Rhode Island, United States, 02906
United States, Texas
Houston AIDS Research Team CRS (31473)
Houston, Texas, United States, 77030 收起 <<
United States, California
... 展开 >>
Living Hope Clinical Foundation
Long Beach, California, United States, 90814
Peter J. Ruane MD Inc
Los Angeles, California, United States, 90036
Anthony Mills MD, Inc.
Los Angeles, California, United States, 90069
La Playa Medical Group and Clinical Research
San Diego, California, United States, 92103
United States, District of Columbia
Dupont Circle Physicians Group, P.C.
Washington, District of Columbia, United States, 20009
Whitman Walker Clinic
Washington, District of Columbia, United States, 20009
Capital Medical Associates, PC
Washington, District of Columbia, United States, 20036
United States, Florida
The Kinder Medical Group
Miami, Florida, United States, 33133
Orlando Immunology Center
Orlando, Florida, United States, 32803
United States, Georgia
Atlanta ID Group
Atlanta, Georgia, United States, 30309
Infectious Disease Specialists of Atlanta
Decatur, Georgia, United States, 30033
United States, Illinois
Northstar Medical Center
Chicago, Illinois, United States, 60657
United States, Massachusetts
Community Research Initiative of New England
Boston, Massachusetts, United States, 02215
United States, Michigan
Be Well Medical Center, P.C.
Berkley, Michigan, United States, 48072
United States, Missouri
Southampton Healthcare, Inc.
St. Louis, Missouri, United States, 63139
United States, Texas
Southwest Infectious Disease Clinical Research, Inc.
Addison, Texas, United States, 75001
Central Texas Clinical Research
Austin, Texas, United States, 78705
United States, Washington
Peter Shalit, M.D.
Seattle, Washington, United States, 98104 收起 <<
United Kingdom
... 展开 >> Brighton & Sussex University Hospitals Nhs Trust
Brighton, United Kingdom
St. Mary's Hospital
London, United Kingdom
St. Stephen's Centre
London, United Kingdom 收起 <<
United States, Florida
... 展开 >>
Daytona Beach, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Pensacola, Florida, United States
Port Saint Lucie, Florida, United States
West Palm Beach, Florida, United States
United States, Georgia
Savannah, Georgia, United States
United States, Illinois
Chicago, Illinois, United States
United States, Massachusetts
Springfield, Massachusetts, United States
United States, Michigan
Dearborn, Michigan, United States
United States, New York
Bronx, New York, United States
Syracuse, New York, United States
United States, North Carolina
Chapel Hill, North Carolina, United States
Greensboro, North Carolina, United States
United States, Pennsylvania
Philadelphia, Pennsylvania, United States
United States, Texas
Bellaire, Texas, United States
Puerto Rico
San Juan Pr, Puerto Rico 收起 <<
Human Immunodeficiency Virus-t... 展开 >>ype 1 Infection 收起 <<
Phase 3
Active, not recruiting
December 31, 2020
Cameroon
... 展开 >>
Douala, Cameroon
Yaounde, Cameroon
Kenya
Eldoret, Kenya
Kangemi, Nairobi, Kenya
Nairobi, Kenya
Nyanza, Kenya
Senegal
Dakar, Senegal
Pikine, Senegal
South Africa
Bloemfontein, South Africa
Johannesburg, South Africa
Soweto, South Africa
Wentworth, Durban, South Africa
Westville, Kwazulu, South Africa
Thailand
Amphur Mueang Nonthaburi, Thailand
Bangkok, Thailand
Chiang Mai, Thailand
Uganda
Entebbe, Uganda
Kampala, Uganda 收起 <<
HIV Nonoccupational Post-expos... 展开 >>ure Prophylaxis in Men Who Have Sex With Men 收起 <<
Phase 4
Completed
-
Australia, New South Wales
... 展开 >>
Sydney Sexual Heatlh Centre
Sydney, New South Wales, Australia, 2000
St Vincents Hospital
Sydney, New South Wales, Australia, 2010
Australia, Victoria
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Melbourne Sexual Health Centre
Melbourne, Victoria, Australia, 3053 收起 <<
HIV Infection
... 展开 >> HAART-treated
Virologically Controlled 收起 <<
Phase 2
Phase 3
Withdrawn(One of the both Fund... 展开 >>er partners decided to stop the study before the initiation thus no product provided and no funding to realize the study) 收起 <<
October 2017
France
... 展开 >> CHU Guadeloupe
Point-a-pitre, Guadeloupe, France, 97159
CHU de Fort de France
Fort de France, Martinique, France, 87261
Chu Jean Minjoz
Besançon, France, 25030
Hôpital Avicenne
Bobigny, France, 93000
Hôpital Jean Verdier
Bondy, France, 93140
CHU de Bordeaux
Bordeaux, France, 33076
CHU de DIJON
Dijon, France, 21079
CHD La Roche sur Yon
La Roche sur Yon, France, 85925
CHU Kremlin Bicêtre
Le Kremlin Bicetre, France, 94275
Hôpital Perpetuel Secours
Levallois-perret, France, 92300
CHU de Nantes
Nantes, France, 44093
Hôpital Saint Louis
Paris Cedex 10, France, 75475
CHU BICHAT - Claude Bernard
Paris cedex 18, France, 75877
CHU Hôtel Dieu Paris
Paris, France, 75004
Hôpital La Pitié Salpêtrière
Paris, France, 75013
Hôpital Necker - enfants Malades
Paris, France, 75015
Hôpital Européen Georges Pompidou
Paris, France, 75908
CHU de Rennes - Hôpital Pontchaillou
Rennes, France, 35000
CH Delafontaine
Saint Denis, France, 93200
CHU Saint Etienne
Saint Etienne, France, 42055
CHU de Strasbourg
Strasbourg, France, 67091
Hôpital FOCH
Suresnes, France, 92150
CHU Toulouse
Toulouse, France, 31059
CHRU de Tours
Tours Cedex 09, France, 37044
CHU de Nancy
VANDOEUVRE LES NANCY cedex, France, 54511 收起 <<
United States, Colorado
... 展开 >>
Univ. of Colorado Denver NICHD CRS
Not yet recruiting
Aurora, Colorado, United States, 80045
Contact: Emily Barr, C.P.N.P., C.N.M., M.S.N. 720-777-6752 emily.barr@childrenscolorado.org
United States, Maryland
Johns Hopkins Univ. Baltimore NICHD CRS
Not yet recruiting
Baltimore, Maryland, United States, 21287
Contact: Aleisha Collinson-Streng, R.N., A.C.R.N. 443-801-7301 acolli14@jhmi.edu
United States, New York
Bronx-Lebanon Hospital Center NICHD CRS
Not yet recruiting
Bronx, New York, United States, 10457
Contact: Martha Cavallo, A.N.P., C.R.N.P. 718-960-1010 mcavallo@bronxleb.org
Jacobi Med. Ctr. Bronx NICHD CRS
Not yet recruiting
Bronx, New York, United States, 10461
Contact: Marlene Burey, R.N., M.S.N., P.N.P. 718-918-4783 marlene.burey@nychhc.org
United States, Tennessee
St. Jude Children's Research Hospital CRS
Not yet recruiting
Memphis, Tennessee, United States, 38105-3678
Contact: Patricia M. Flynn, M.D. 901-595-2338 pat.flynn@stjude.org
United States, Washington
Seattle Children's Research Institute CRS
Not yet recruiting
Seattle, Washington, United States, 98101
Contact: Amanda Robson Nuss, B.S. 206-884-1535 amanda.robson@seattlechildrens.org
Puerto Rico
San Juan City Hosp. PR NICHD CRS
Not yet recruiting
San Juan, Puerto Rico, 00936
Contact: Lizbeth Fabregas-Troche, B.S., M.S. 787-764-3083 lfabregas@sanjuanciudadpatria.com 收起 <<
United Kingdom
... 展开 >> Royal Sussex County Hospital
Brighton, Sussex, United Kingdom, BN2 5BE
St. Thomas's Hospital
London, United Kingdom, SE1 7EH
St Stephen's Centre
London, United Kingdom, SW10 9TH
St. Mary's Hospital
London, United Kingdom, W2 1NY 收起 <<
Human Immuno Deficiency (HIV) ... 展开 >>Infection 收起 <<
Phase 2
Recruiting
August 20, 2027
United States, New York
... 展开 >>
SUNY Upstate Medical University
Recruiting
Syracuse, New York, United States, 13210
United States, Tennessee
St Jude Children's Research Hospital
Completed
Memphis, Tennessee, United States, 38105
United States, Virginia
Children'S Hospital of the King'S Daughters
Withdrawn
Norfolk, Virginia, United States, 23507
India
Yr Gaitonde Center For Aids Research and Education
Completed
Chennai, India, 600113
Kasturba Medical College Hospital
Completed
Mangalore, India, 575001
Kenya
Kenya Medical Research Institute/Walter Reed Project
Not yet recruiting
Kericho, Kenya, 20200
KAVI Institute of Clinical Research
Recruiting
Nairobi, Kenya, 254
Romania
Spitalul de Boli Infectioase si Tropicale 'Dr. Victor Babes'
Completed
Bucuresti, Romania, 030317
South Africa
Boanerges Clinical Research
Completed
Bloemfontein, South Africa, 9301
Josha Research
Recruiting
Bloemfontein, South Africa, 9301
Jan Fourie Medical Practice
Completed
Dundee, South Africa, 3000
University of KwaZulu-Natal
Withdrawn
Durban, South Africa, 4001
Harriet Shezi Childrens Clinic, Paediatric Department
Withdrawn
Johannesburg Gauteng, South Africa, 2013
Mzansi Ethical Research Centre
Recruiting
Middelburg, South Africa, 1055
Triple M Research
Withdrawn
Port Elizabeth, South Africa, 6070
Synexuss Sastanza
Completed
Pretoria, South Africa, 0122
Limpopo Clinical Research Initiative
Recruiting
Thabazimbi, South Africa, 380
East Rand Urology Research Unit
Not yet recruiting
Vosloorus, South Africa, 1475
Thailand
Thai Red Cross Aids Research Centre
Completed
Bangkok, Thailand, 10330
Queen Sirikit National Institute of Child Health
Withdrawn
Bangkok, Thailand, 10400
Bamrasnaradura Infectious Disease Institute
Recruiting
Nonthaburi, Thailand, 11000
Uganda
Mrc/ Uvri Uganda Research Unit on Aids
Not yet recruiting
Entebbe, Uganda
Joint Clinical Research Centre
Recruiting
Kampala, Uganda, 10005
Makerere University Medical School
Withdrawn
Kampala, Uganda
Ukraine
Center Clinic for treatment HIV positive children
Completed
Kiev, Ukraine, 01135 收起 <<
United States, New Jersey
... 展开 >>
New Jersey Medical School Clinical Research Center
Newark, New Jersey, United States, 07103
United States, New York
Bronx Prevention Center
Bronx, New York, United States, 10451
South Africa
Emavundleni Clinical Research Site
Cape Town, South Africa
Zimbabwe
Spilhaus Clinical Research Site
Belgravia, Harare, Zimbabwe 收起 <<
United States, Texas
... 展开 >>
Therapeutic Concepts, P.A.
Not yet recruiting
Houston, Texas, United States, 77004
Contact: Joseph C. Gathe, M.D. 713-526-9821 drgathe@josephgathe.com
Contact: Valerie H. Davis, B.S. 713-526-9821 vdavis@josephgathe.com
Principal Investigator: Joseph C. Gathe, M.D.
Therapeutic Concepts, PA
Houston, Texas, United States, 77004 收起 <<
Human Immunodeficiency Virus T... 展开 >>ype 1 收起 <<
Phase 2
Recruiting
November 4, 2031
South Africa
... 展开 >> Josha Research
Recruiting
Bloemfontein, South Africa, 9301
Jan Fourie Medical Practice
Completed
Dundee, South Africa, 2930 收起 <<
Human Immunodeficiency Virus I... 展开 >>nfections 收起 <<
Phase 3
Recruiting
August 31, 2020
India
... 展开 >> St.Johns Medical College and Hospital
Not yet recruiting
Bengaluru, India, 560034
YRGCARE
Not yet recruiting
Chennai, India, 600113
Manipal University-Kasturba Medical College
Recruiting
Mangalore, India, 575001
Lata Mangeshkar Hospital
Recruiting
Nagpur, India, 440001
Deenanath Mangeshkar Hospital and Research Centre
Recruiting
Pune, India, 411004 收起 <<
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