Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 酶学
/
药物分析
酶抑制剂 内分泌学/激素
/
ACE
药物标准品 血管紧张素转化酶抑制剂
/ Ramipril

雷米普利 /Ramipril {[allProObj[0].p_purity_real_show]}

货号：A271148 同义名： HOE-498

Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ramipril 化学结构 CAS号：87333-19-5
Ramipril 化学结构
CAS号：87333-19-5
Ramipril 3D分子结构
CAS号：87333-19-5
Ramipril 化学结构 CAS号：87333-19-5
Ramipril 3D分子结构 CAS号：87333-19-5
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Ramipril 纯度/质量文件 产品仅供科研

货号：A271148 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
• PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]
更多 >

Ramipril 生物活性

靶点

  • ACE

    ACE, IC50:5 nM
描述 Ramipril is a angiotensin converting enzyme (ACE) inhibitor. Ramipril benefited left ventricular remodeling by reducing fibrosis and collagen accumulation in the left ventricle of rats after myocardial infarction[3]. Ramipril inhibits systolic blood pressure (SBP) with IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR). Cardiac ACE activity was greatly reduced by ramipril independently of SBP reduction and dosage[4]. Prolonged ramiprilat treatment increased ACE expression in primary cultures of human endothelial cells and in vivo (mouse lung) [5].

Ramipril 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00732069 End Stage Renal Failure on Dia... 展开 >>lysis Complication of Hemodialysis 收起 << Phase 2 Completed - United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37323 收起 <<
NCT00732069 - Completed - -
NCT01225445 Biopsy-confirmed IgA Nephropat... 展开 >>hy Proteinuria Less Than 0.5 g Per Day Normal Blood Pressure Serum Creatinine Below 120 Umol/l 收起 << Phase 3 Completed - Hong Kong ... 展开 >> Department of Medicine & Therapeutics, Prince of Wales Hospital Shatin, Hong Kong 收起 <<

Ramipril 参考文献

[1]Kohlstedt K, Brandes RP, et al. Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res. 2004 Jan 9;94(1):60-7. Epub 2003 Nov 13.

[2]Stevens BR, Phillips MI, et al. Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C. 1988;91(2):493-7.

[3]Wei Q, Liu H, Liu M, Yang C, Yang J, Liu Z, Yang P. Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure. Sci Rep. 2016 Sep 19;6:33677. doi: 10.1038/srep33677. PMID: 27642098; PMCID: PMC5027547.

[4]Raasch W, Jöhren O, Schwartz S, Gieselberg A, Dominiak P. Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens. 2004 Mar;22(3):611-8. doi: 10.1097/00004872-200403000-00025. PMID: 15076168.

[5]Kohlstedt K, Brandes RP, Müller-Esterl W, Busse R, Fleming I. Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res. 2004 Jan 9;94(1):60-7. doi: 10.1161/01.RES.0000107195.13573.E4. Epub 2003 Nov 13. PMID: 14615289.

Ramipril 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.01mL

4.80mL

2.40mL

Ramipril 技术信息

CAS号87333-19-5
分子式C23H32N2O5
分子量 416.511
别名 HOE-498
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(252.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.4 mM)，配合低频超声助溶
动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water 30 mg/mL suspension

Tags: Ramipril | 87333-19-5 | HOE-498 | HOE498 | HOE 498 | Apoptosis Inducer | Metabolic Enzyme/Protease | Apoptosis | Angiotensin-converting Enzyme (ACE) | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ramipril 纯度/质量文件 | Ramipril 生物活性 | Ramipril 临床数据 | Ramipril 参考文献 | Ramipril 实验方案 | Ramipril 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z