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雷米普利 /Ramipril {[allProObj[0].p_purity_real_show]}

货号:A271148 同义名: HOE-498

Ramipril是一种 ACE 抑制剂,IC50 值为 5 nM,常用于治疗高血压和心衰等疾病。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ramipril 化学结构 CAS号:87333-19-5
Ramipril 化学结构
CAS号:87333-19-5
Ramipril 3D分子结构
CAS号:87333-19-5
Ramipril 化学结构 CAS号:87333-19-5
Ramipril 3D分子结构 CAS号:87333-19-5
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Ramipril 纯度/质量文件 产品仅供科研

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Ramipril 生物活性

靶点
  • ACE

    ACE, IC50:5 nM

描述 Ramipril is a angiotensin converting enzyme (ACE) inhibitor. Ramipril benefited left ventricular remodeling by reducing fibrosis and collagen accumulation in the left ventricle of rats after myocardial infarction[3]. Ramipril inhibits systolic blood pressure (SBP) with IC50 of 1.97 mg/kg in spontaneously hypertensive rats (SHR). Cardiac ACE activity was greatly reduced by ramipril independently of SBP reduction and dosage[4]. Prolonged ramiprilat treatment increased ACE expression in primary cultures of human endothelial cells and in vivo (mouse lung) [5].

Ramipril 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00732069 End Stage Renal Failure on Dia... 展开 >>lysis Complication of Hemodialysis 收起 << Phase 2 Completed - United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37323 收起 <<
NCT00732069 - Completed - -
NCT01225445 Biopsy-confirmed IgA Nephropat... 展开 >>hy Proteinuria Less Than 0.5 g Per Day Normal Blood Pressure Serum Creatinine Below 120 Umol/l 收起 << Phase 3 Completed - Hong Kong ... 展开 >> Department of Medicine & Therapeutics, Prince of Wales Hospital Shatin, Hong Kong 收起 <<

Ramipril 参考文献

[1]Kohlstedt K, Brandes RP, et al. Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res. 2004 Jan 9;94(1):60-7. Epub 2003 Nov 13.

[2]Stevens BR, Phillips MI, et al. Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C. 1988;91(2):493-7.

[3]Wei Q, Liu H, Liu M, Yang C, Yang J, Liu Z, Yang P. Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure. Sci Rep. 2016 Sep 19;6:33677. doi: 10.1038/srep33677. PMID: 27642098; PMCID: PMC5027547.

[4]Raasch W, Jöhren O, Schwartz S, Gieselberg A, Dominiak P. Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens. 2004 Mar;22(3):611-8. doi: 10.1097/00004872-200403000-00025. PMID: 15076168.

[5]Kohlstedt K, Brandes RP, Müller-Esterl W, Busse R, Fleming I. Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res. 2004 Jan 9;94(1):60-7. doi: 10.1161/01.RES.0000107195.13573.E4. Epub 2003 Nov 13. PMID: 14615289.

Ramipril 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.01mL

4.80mL

2.40mL

Ramipril 技术信息

CAS号87333-19-5
分子式C23H32N2O5
分子量 416.511
别名 HOE-498
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解度

DMSO: 105 mg/mL(252.09 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.4 mM),配合低频超声助溶

动物实验配方

30% PEG400+0.5% Tween80+5% propylene glycol+water 30 mg/mL suspension

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