Ramelteon (administered orally; 0.1 and 1 mg/kg) effectively speeds up the adjustment of activity rhythms to new light-dark cycles in running wheel tests^[3].

Ramelteon (administered orally; 3, 10, and 30 mg/kg) does not impair learning or memory as evidenced by performance in water maze tasks and the delayed match to position tasks in rats, suggesting no abuse potential for MT1/MT2 receptor agonists^[3].

Ramelteon (administered orally at doses of 0.0001, 0.001, 0.01, and 0.1 mg/kg every 8 hours) markedly reduces wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, enhances slow-wave sleep at the same doses, and boosts rapid eye movement sleep at 0.1 mg/kg^[4].