货号:A1166728 同义名: Robert Costa Memorial drug-1
RCM-1是一种 forkhead box M1 (FOXM1) 抑制剂,在 U2OS 细胞中的 EC50 为 0.72 μM。RCM-1 阻止了核定位并增加了 FOXM1 的蛋白酶体降解,可减少癌变和核 β-catenin表达。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50μL*10mM(DMSO) | ¥179 | 咨询 | |
100μL*10mM(DMSO) | ¥410 | 咨询 | |
250μL*10mM(DMSO) | ¥786 | 咨询 | |
500μL*10mM(DMSO) | ¥1127 | 咨询 | |
10mM*1mL(DMSO) | ¥1485 | 咨询 | |
1100μL*10mM(DMSO) | ¥289 | 咨询 | |
1250μL*10mM(DMSO) | ¥579 | 咨询 | |
5mg | ¥945 | 咨询 | |
1500μL*10mM(DMSO) | ¥959 | 咨询 | |
10mg | ¥1417 | 咨询 | |
25mg | ¥2709 | 咨询 | |
50mg | ¥3891 | 咨询 | |
100mg | ¥5448 | 咨询 | |
1g | ¥25137 | 咨询 |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | FOXM1 is a transcription factor from the Forkhead box (FOX) family that is critical for the differentiation of goblet cells from airway progenitor cells. RCM-1 is a FOXM1 inhibitor which inhibits goblet cell metaplasia and IL-13 signaling, and RCM-1 is used to treat patients with asthma and other chronic airway diseases. RCM-1 inhibited GFP-FOXM1 with an EC50 of 0.72 μM in U2OS cells. Furthermore, RCM-1 inhibited the expression of FOXM1 target genes Plk1 and Cdc25B, a functional readout of FOXM1 transcriptional activity. In addition to GFP-FOXM1, RCM-1 decreased the abundance of endogenous FOXM1 in primary human airway epithelial cells cultured on an air-liquid interface without altering that of other transcription factors. In vivo, RCM-1 treatment decreased the abundance of endogenous FOXM1 in wild-type BALB/c mice. RCM-1 protected lungs from HDM-induced airway hyperreactivity and preserved lung function in BALB/c mice. Moreover, RCM-1 decreased goblet cell metaplasia and airway resistance and improved lung function in IL-13-treated mice[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM | 2.36mL 0.47mL 0.24mL | 11.78mL 2.36mL 1.18mL | 23.55mL 4.71mL 2.36mL |
CAS号 | 339163-65-4 |
分子式 | C20H12N2OS4 |
分子量 | 424.582 |
别名 | Robert Costa Memorial drug-1 |
运输 | 蓝冰 |
存储条件 | 液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Room temperature |
溶解度 | DMSO: 16 mg/mL(37.68 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |