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RCM-1

货号:A1166728 同义名: Robert Costa Memorial drug-1

RCM-1是一种 forkhead box M1 (FOXM1) 抑制剂,在 U2OS 细胞中的 EC50 为 0.72 μM。RCM-1 阻止了核定位并增加了 FOXM1 的蛋白酶体降解,可减少癌变和核 β-catenin表达。

RCM-1 化学结构 CAS号:339163-65-4
RCM-1 化学结构
CAS号:339163-65-4
RCM-1 3D分子结构
CAS号:339163-65-4
RCM-1 化学结构 CAS号:339163-65-4
RCM-1 3D分子结构 CAS号:339163-65-4
规格 价格 库存 数量
50μL*10mM(DMSO) ¥179 咨询
100μL*10mM(DMSO) ¥410 咨询
250μL*10mM(DMSO) ¥786 咨询
500μL*10mM(DMSO) ¥1127 咨询
10mM*1mL(DMSO) ¥1485 咨询
1100μL*10mM(DMSO) ¥289 咨询
1250μL*10mM(DMSO) ¥579 咨询
5mg ¥945 咨询
1500μL*10mM(DMSO) ¥959 咨询
10mg ¥1417 咨询
25mg ¥2709 咨询
50mg ¥3891 咨询
100mg ¥5448 咨询
1g ¥25137 咨询
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RCM-1 纯度/质量文件 产品仅供科研

货号:A1166728 标准纯度:
批次查询: 批次纯度:

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RCM-1 生物活性

描述 FOXM1 is a transcription factor from the Forkhead box (FOX) family that is critical for the differentiation of goblet cells from airway progenitor cells. RCM-1 is a FOXM1 inhibitor which inhibits goblet cell metaplasia and IL-13 signaling, and RCM-1 is used to treat patients with asthma and other chronic airway diseases. RCM-1 inhibited GFP-FOXM1 with an EC50 of 0.72 μM in U2OS cells. Furthermore, RCM-1 inhibited the expression of FOXM1 target genes Plk1 and Cdc25B, a functional readout of FOXM1 transcriptional activity. In addition to GFP-FOXM1, RCM-1 decreased the abundance of endogenous FOXM1 in primary human airway epithelial cells cultured on an air-liquid interface without altering that of other transcription factors. In vivo, RCM-1 treatment decreased the abundance of endogenous FOXM1 in wild-type BALB/c mice. RCM-1 protected lungs from HDM-induced airway hyperreactivity and preserved lung function in BALB/c mice. Moreover, RCM-1 decreased goblet cell metaplasia and airway resistance and improved lung function in IL-13-treated mice[2].

RCM-1 参考文献

[1]ARYL SULFONOHYDRAZIDES.WO2018057550A1.

[2]Sun L, et al. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci Signal. 2017 Apr 18;10(475):eaai8583

RCM-1 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.55mL

4.71mL

2.36mL

RCM-1 技术信息

CAS号339163-65-4
分子式C20H12N2OS4
分子量 424.582
别名 Robert Costa Memorial drug-1
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 16 mg/mL(37.68 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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