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/ Prulifloxacin

普卢利沙星 /Prulifloxacin {[allProObj[0].p_purity_real_show]}

货号：A151816 同义名： NM441;AF 3013

Prulifloxacin is the prodrug of ulifloxacin, which is a broad-spectrum oral fluoroquinolone antibacterial agent.

Prulifloxacin 化学结构 CAS号：123447-62-1
Prulifloxacin 化学结构
CAS号：123447-62-1
Prulifloxacin 3D分子结构
CAS号：123447-62-1
Prulifloxacin 化学结构 CAS号：123447-62-1
Prulifloxacin 3D分子结构 CAS号：123447-62-1
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Prulifloxacin 纯度/质量文件 产品仅供科研

货号：A151816 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Prulifloxacin 生物活性

描述 Prulifloxacin is a new fluoroquinolone with indications in the treatment of urinary tract infection and acute exacerbations of chronic bronchitis[3]. Prulifloxacin is the active metabolite of ulifloxacin with a broad in vitro activity spectrum against Gram positive and negative bacteria and among fluoroquinolones has the lowest power of inducing resistance. Prulifloxacin shows a high safety profile: it is the fluoroquinolone with the lowest risk of cardiac arrhythmias for prolongation of the QT interval; the CNS(central nervous system) penetration is negligible; in women prulifloxacin does not affect the lactobacillary component of the vaginal microbiota, lowering the risk of genito-urinary tract infections[4]. In well-designed clinical trials, prulifloxacin 600 mg administered once daily for 10 days in patients with AECB (acute exacerbations of chronic bronchitis) showed good clinical and bacteriological efficacy[5].

Prulifloxacin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00392574 Acute Gastroenteritis in Adult... 展开 >> Travelers 收起 << Phase 3 Completed - United States, Pennsylvania ... 展开 >> INC Research New Hope, Pennsylvania, United States, 18938 收起 <<
NCT00448422 Acute Bacterial Gastroenteriti... 展开 >>s 收起 << Phase 3 Completed - India ... 展开 >> Goa Medical College Bambolim, Goa, India 收起 <<
NCT02130713 Chronic Bacterial Prostatitis Phase 4 Completed - Italy ... 展开 >> policlinico Umberto I - Department of Gynecological-Obstetrics Sciences and Urological Sciences Roma, Italy, 00161 收起 <<

Prulifloxacin 参考文献

[1]Chen Y, Yang H, et al. Prulifloxacin versus levofloxacin in the treatment of respiratory and urinary tract infections: a multicentre, double-blind, randomized controlled clinical trial. Chemotherapy. 2012;58(3):249-56.

[2]Rafailidis PI, Polyzos KA, et al. Prulifloxacin: a review focusing on its use beyond respiratory and urinary tract infections. Int J Antimicrob Agents. 2011 Apr;37(4):283-90.

[3]Blasi F, Aliberti S, Tarsia P, Santus P, Centanni S, Allegra L. Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis. Int J Chron Obstruct Pulmon Dis. 2007;2(1):27–31

[4]Geddes AM, Klugman KP, Rolinson GN. Introduction: historical perspective and development of amoxicillin/clavulanate. Int J Antimicrob Agents. 2007;30 Suppl 2:S109–S112

[5]Cazzola M, Salvatori E, Dionisio P, Allegra L. Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis. Pulm Pharmacol Ther. 2006;19 Suppl 1:30–37

Prulifloxacin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.84mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL

Prulifloxacin 技术信息

CAS号123447-62-1
分子式C21H20FN3O6S
分子量 461.463
别名 NM441;AF 3013
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 12 mg/mL(26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Prulifloxacin | 123447-62-1 | NM441 | NM 441 | NM-441 | Anti-infection | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Prulifloxacin 纯度/质量文件 | Prulifloxacin 生物活性 | Prulifloxacin 临床数据 | Prulifloxacin 参考文献 | Prulifloxacin 实验方案 | Prulifloxacin 技术信息

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