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Pritelivir mesylate {[allProObj[0].p_purity_real_show]}

货号：A1466931 同义名： AIC316 mesylate;BAY 57-1293 mesylate Ambeed 开学季，买赠积分，赢豪礼

Pritelivir, also known as AIC-316 and BAY 57-1293, is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations.

Pritelivir mesylate 化学结构 CAS号：1428333-96-3
Pritelivir mesylate 化学结构
CAS号：1428333-96-3
Pritelivir mesylate 3D分子结构
CAS号：1428333-96-3
Pritelivir mesylate 化学结构 CAS号：1428333-96-3
Pritelivir mesylate 3D分子结构 CAS号：1428333-96-3
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Pritelivir mesylate 纯度/质量文件 产品仅供科研

货号：A1466931 标准纯度： {[allProObj[0].p_purity_real_show]}
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Pritelivir mesylate 生物活性

描述 Pritelivir (AIC316) is an inhibitor of the viral helicase-primase complex, which exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2[1].
体内研究

Pritelivir is a pioneering agent in antiviral treatment that interrupts HSV replication by targeting the viral helicase-primase enzyme complex.

Pritelivir, at dosages ranging from 0.03 to 45 mg/kg, significantly improves survival rates and, at 0.3 to 30 mg/kg, reduces mortality against HSV-1, E-377, thereby demonstrating potent and breakthrough antiviral efficiency with the potential for managing life-threatening HSV-1 and -2 infections, including herpes simplex encephalitis.

Compared with the control treatment group, 0.1 or 0.3 mg/kg/ dose of pritlivir combined with acyclovir (10 mg/kg/ dose) had a protective effect against HSV-2 MS strains [3].

Pritelivir mesylate 参考文献

[1]Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483.

[2]Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370(3):201-10.

[3]Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6.

Pritelivir mesylate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.03mL

2.01mL

1.00mL

20.06mL

4.01mL

2.01mL

Pritelivir mesylate 技术信息

CAS号1428333-96-3
分子式C19H22N4O6S3
分子量 498.596
别名 AIC316 mesylate;BAY 57-1293 mesylate
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 85 mg/mL(170.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Pritelivir | 1428333-96-3 | AIC316 | BAY 57-1293 | AIC 316 | AIC-316 | Helicase-primase Complex Inhibitor | Anti-infection | HSV | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pritelivir mesylate 纯度/质量文件 | Pritelivir mesylate 生物活性 | Pritelivir mesylate 参考文献 | Pritelivir mesylate 实验方案 | Pritelivir mesylate 技术信息

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