货号:A719383 同义名: 聚胞苷酸 / Poly(I:C)
Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Toll-like receptor-3 (TLR-3) belong to the Toll-like receptors family, it is mainly expressed on immune cells where it senses pathogen-associated molecular patterns and initiates innate immune response[3]. Polyinosinic-polycytidylic acid [poly (I:C)] can act as a dsRNA molecule and interacts with TLR-3 of microglia cells to evoke the immune system, thus mimicking the viral infection. Early life exposure to poly (I:C) has a long-term effect and impairs learning and memory, probably through TNF-α mediated neuroinflammation and alteration in the expression of memory associated genes in frontal cortex and hippocampus of rats[4]. Poly (I:C) exclusively stimulated the expression of interferon (IFN) β, IFNλ1, and the IFN-stimulated gene OAS2. Poly (I:C) also significantly increased secretion of elafin, CCL20, and RANTES. Secretions from poly (I:C)-treated fibroblasts had both greater anti-HIV activity and induced higher levels of CD4 + T cell chemotaxis than those from LPS-treated cells[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01245673 | Myeloma | Phase 2 | Active, not recruiting | August 2018 | United States, Maryland ... 展开 >> University of Maryland Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 << |
NCT02425306 | Melanoma | Phase 1 Phase 2 | Terminated(Slow accrual to par... 展开 >>t 2 of the study. Accrual to part 1 is complete.) 收起 << | - | United States, Virginia ... 展开 >> Cancer Center at the University of Virginia Charlottesville, Virginia, United States, 22908 收起 << |
NCT03121677 | Follicular Lymphoma | Phase 1 | Recruiting | January 31, 2028 | United States, Missouri ... 展开 >> Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Todd A Fehinger, M.D., Ph.D. 314-362-5654 tfehnige@wustl.edu Principal Investigator: Todd A Fehniger, M.D., Ph.D. Sub-Investigator: Neha Mehta-Shah, M.D. Sub-Investigator: Jeffrey Ward, M.D., Ph.D. Sub-Investigator: Nancy L Bartlett, M.D. Sub-Investigator: Brad Kahl, M.D. Sub-Investigator: Amanda Cashen, M.D. Sub-Investigator: Armin Ghobadi, M.D. Sub-Investigator: John DiPersio, M.D., Ph.D. Sub-Investigator: William E Gillanders, M.D. Sub-Investigator: Malachi Griffith, Ph.D. Sub-Investigator: Obi Griffith, Ph.D. Sub-Investigator: Max Artyomov, Ph.D. 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.49mL 0.30mL 0.15mL |
7.45mL 1.49mL 0.74mL |
14.89mL 2.98mL 1.49mL |
CAS号 | 24939-03-5 |
分子式 | (C10H13N4O8P)x.(C9H14N3O8P)x |
分子量 |
别名 | 聚胞苷酸 ;Poly(I:C) |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
H2O: 50 mg/mL,配合低频超声助溶 |
动物实验配方 |