聚氧乙烯-聚氧丙烯共聚物又称为泊洛沙姆(Poloxamer),由聚氧乙烯和聚氧丙烯聚合而成,随着分子中聚氧乙烯部分比例的增加,水溶性增加;分子中聚氧丙烯部分比例的增加,则水溶性下降。它是一种非离子型高分子表面活性剂,常作为各种制剂和给药系统中的辅料或助溶剂。
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描述 | Poloxamer 188, a nonionic linear copolymer, exhibits surfactant properties and demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective effects across various tissue injury models, making it suitable for drug delivery applications[1][2][3][4]. As a non-ionic linear copolymer, Poloxam188 has the capability of surfactant and has antithrombotic, anti-inflammatory and cytoprotective effects in the case of tissue damage.[1]. |
体内研究 | An intravenous dose of 150 mg/kg of Poloxamer 188, administered 240 minutes apart, effectively mitigates ischemia-reperfusion-associated muscular edema and lipid peroxidation[3]. |
体外研究 | At concentrations ranging from 10 to 1000 μM for five hours, Poloxamer 188 provides protection to cerebral microvascular endothelial cells (MBEC) in mice[2]. The incorporation of Docetaxel into PLGA/poloxamer 188 nanoparticles enhances drug uptake and cytotoxicity in docetaxel-resistant MCF-7 TAX30 human breast cancer cells, compared to Docetaxel-loaded PLGA nanoparticles[4]. |
CAS号 | 9003-11-6 |
分子式 | (C3H6O.C2H4O)x |
分子量 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 |
DMSO: 105 mg/mL,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL,配合低频超声助溶 |
动物实验配方 |