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吡美莫司 /Pimecrolimus {[allProObj[0].p_purity_real_show]}

货号：A944531 同义名： SDZ-ASM 981;Elidel Ambeed 开学季，买赠积分，赢豪礼

Pimecrolimus is an immunomodulating agent of the calcineurin inhibitor class， effective in various inflammatory skin diseases, including seborrheic dermatitis, cutaneous lupus erythematosus, oral lichen planus, vitiligo and psoriasis.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Pimecrolimus 化学结构 CAS号：137071-32-0
Pimecrolimus 化学结构
CAS号：137071-32-0
Pimecrolimus 3D分子结构
CAS号：137071-32-0
Pimecrolimus 化学结构 CAS号：137071-32-0
Pimecrolimus 3D分子结构 CAS号：137071-32-0
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Pimecrolimus 纯度/质量文件 产品仅供科研

货号：A944531 标准纯度： {[allProObj[0].p_purity_real_show]}
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Pimecrolimus 生物活性

描述 Calcineurin, a critical calcium-activated protein phosphatase, is required for many functions in a variety of tissues: learning and memory, renal function, and the immune response. Pimecrolimus, a novel calcineurin inhibitor closely related to tacrolimus, is also being developed for atopic dermatitis therapy[3]. Pimecrolimus selectively inhibited the activation of T cells and mast cells, two key events in the pathogenesis of AD (atopic dermatitis). In rat model of immunosuppression, the graft-versus-host (GvH) reaction is inhibited by pimecrolimus in a dose-dependent fashion after subcutaneous administration with an ID50 (dose inhibiting the swelling observed in controls by 50%) of 20 mg/kg[4]. In the pig model a statistically significant anti-inflammatory effect was observed at concentrations as low as 0.04%. In the allogenic kidney transplantation model, pimecrolimus prevented organ rejection at oral doses of 15.6 mg/kg and higher. Pimecrolimus doses of 20 mg b.i.d and 30 mg b.i.d. were observed to have the greatest reduction in the Psoriasis Area and Severity Index (PASI) of 60% and 75%, respectively, compared to 4% for placebo[5]..
作用机制 The mechanism of action of pimecrolimus is the blockage of T cell activation involving its binding to macrophilin-12[5].

Pimecrolimus 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00377962 Disorder Related to Cardiac Tr... 展开 >>ansplantation 收起 << Phase 4 Completed - Denmark ... 展开 >> Novartis Investigative Site Arhus, Denmark, DK-8200 Novartis Investigative Site Copenhagen, Denmark, 2100 Norway Novartis Investigative Site Oslo, Norway Sweden Novartis Investigative Site Goteborg, Sweden, 413 45 Novartis Investigative Site Linkoping, Sweden, 581 85 Novartis Investigative Site Lund, Sweden, 22185 收起 <<
NCT00377962 - Completed - -
NCT00148746 Moderate to Severe Atopic Derm... 展开 >>atitis 收起 << Not Applicable Completed - Germany ... 展开 >> Department of Dermatology, TU Dresden Dresden, Germany, 01307 收起 <<

Pimecrolimus 参考文献

[1]Gupta AK, Chow M. Pimecrolimus: a review. J Eur Acad Dermatol Venereol. 2003 Sep;17(5):493-503.

[2]Nghiem P, Pearson G, et al. Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol. 2002 Feb;46(2):228-41.

[3]Nghiem P, Pearson G, Langley RG. Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol. 2002 Feb;46(2):228-41

[4]Stuetz A, Grassberger M, Meingassner JG. Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. Semin Cutan Med Surg. 2001 Dec;20(4):233-41

[5]Gupta AK, Chow M. Pimecrolimus: a review. J Eur Acad Dermatol Venereol. 2003 Sep;17(5):493-503

Pimecrolimus 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.23mL

0.25mL

0.12mL

6.17mL

1.23mL

0.62mL

12.34mL

2.47mL

1.23mL

Pimecrolimus 技术信息

CAS号137071-32-0
分子式C43H68ClNO11
分子量 810.453
别名 SDZ-ASM 981;Elidel;Rizan;Brand name: Aregen;33-epi-Chloro-33-desoxyascomycin;Pimecrolimusum;ASM-981
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 30 mg/mL(37.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Pimecrolimus | SDZ-ASM 981;Elidel;Rizan;33-epi-Chloro-33-desoxyascomycin;Pimecrolimusum;ASM-981 | Calcineurin | AmBeed-信号通路专用抑制剂 | Pimecrolimus 纯度/质量文件 | Pimecrolimus 生物活性 | Pimecrolimus 临床数据 | Pimecrolimus 参考文献 | Pimecrolimus 实验方案 | Pimecrolimus 技术信息

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