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奥泽沙星 /Ozenoxacin {[allProObj[0].p_purity_real_show]}

货号：A724760 同义名： T-3912

Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

Ozenoxacin 化学结构 CAS号：245765-41-7
Ozenoxacin 化学结构
CAS号：245765-41-7
Ozenoxacin 3D分子结构
CAS号：245765-41-7
Ozenoxacin 化学结构 CAS号：245765-41-7
Ozenoxacin 3D分子结构 CAS号：245765-41-7
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Ozenoxacin 纯度/质量文件 产品仅供科研

货号：A724760 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ozenoxacin 生物活性

描述 Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections. Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10-10 and 5.3 × 10-10, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin[2]. Ozenoxacin, a novel non-fluorinated topical quinolone antimicrobial, has demonstrated efficacy in impetigo. In vitro studies have demonstrated high potency of ozenoxacin against staphylococci and streptococci including resistant strains of S. aureus. Clinical trials of ozenoxacin in patients with impetigo reported high clinical and microbiological success rates[3].

Ozenoxacin 参考文献

[1]López Y, Tato M, Espinal P, et al. In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. Antimicrob Agents Chemother. 2013;57(12):6389-6392

[2]López Y, Tato M, Espinal P, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. J Antimicrob Chemother. 2015;70(1):57-61

[3]Vila J, Hebert AA, Torrelo A, et al. Ozenoxacin: a review of preclinical and clinical efficacy. Expert Rev Anti Infect Ther. 2019;17(3):159-168

Ozenoxacin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.52mL

5.50mL

2.75mL

Ozenoxacin 技术信息

CAS号245765-41-7
分子式C21H21N3O3
分子量 363.41
别名 T-3912
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 2 mg/mL(5.5 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ozenoxacin | 245765-41-7 | T-3912 | T3912 | T 3912 | Bacterial Inhibitor | Anti-infection | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ozenoxacin 纯度/质量文件 | Ozenoxacin 生物活性 | Ozenoxacin 参考文献 | Ozenoxacin 实验方案 | Ozenoxacin 技术信息

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