规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10mM*1mL(DMSO) | ¥6435 | 现货 | - + |
1mg | ¥2080 | 现货 | - + |
5mg | ¥5031 | 现货 | - + |
10mg | ¥8550 | 现货 | - + |
25mg | ¥15259 | 现货 | - + |
100mg | ¥38160 | 咨询 |
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描述 | O-linked N-acetylglucosamine (OGlcNAc) transferase (OGT) is an essential enzyme responsible for nucleocytoplasmic glycosylation. OSMI-4 is a potent OGT inhibitor with an EC50 value of ~3μM. Treatment of HEK293T cell lysates with OSMI-4 for 24 hours almost completely reduced the level of OGlcNAc at a concentration of 5μM. Cells treated with 20μM of OSMI-4 for 48 hours also showed decreased levels of HCF-1 cleavage products and the appearance of uncleaved HCF-1 compared to the control group. Also in HEK293T cells, 2-hour treatment with 10μM of OSMI-4 resulted in an increase in OGT’s detained intron splicing[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM | 1.66mL 0.33mL 0.17mL | 8.28mL 1.66mL 0.83mL | 16.55mL 3.31mL 1.66mL |
CAS号 | 2260791-14-6 |
分子式 | C27H26ClN3O7S2 |
分子量 | 604.094 |
别名 | |
运输 | 蓝冰 |
存储条件 | 液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 | DMSO: 60 mg/mL(99.32 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |