There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
NNK, a nitrosated derivative of nicotine, concurrently induces phosphorylation of Bcl2 uniquely at Ser70 and c-Myc at Thr58 and Ser62 via activation of both ERK1/2 and PKCα[1]. NNK promotes the survival and proliferation of human lung cancer cells and can be utilized in constructing lung cancer mouse models[2].
体外研究
NNK (100 pM; 0-60 min) triggers the activation of PKCα and MAPKs ERK1/2, which directly leads to c-Myc phosphorylation[1].
NNK (100 pM; 96 hours) boosts the proliferation of cells expressing wild-type (WT) but not the AA mutant of c-Myc[1].
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