N-desmethyl Enzalutamide
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货号：A526563
同义名：
N-desmethyl MDV 3100
N-desmethyl Enzalutamide 是 Enzalutamide 的活性代谢物，其主要和次要药效学作用与 Enzalutamide 本身相似，浓度与 Enzalutamide 在血浆中的浓度相当。
N-desmethyl Enzalutamide 化学结构
N-desmethyl Enzalutamide 3D分子结构
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N-desmethyl Enzalutamide 纯度/质量文件 产品仅供科研
货号：A526563
标准纯度：
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产品说明书
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N-desmethyl Enzalutamide 质控信息
Cyproterone acetate
++++
Androgen Receptor, IC50: 7.1 nM
98%
Apalutamide
+++
Androgen Receptor, IC50: 16 nM
98%
AZD3514
+
Androgen Receptor, Ki: 2.2 μM
98%
Darolutamide
++++
Androgen receptor, Ki: 11 nM
98%
Flutamide
+++
Androgen Receptor, Ki: 55 nM
98%
Galeterone
++
Androgen Receptor, IC50: 384 nM
98%
Enzalutamide
+++
Androgen Receptor, IC50: 36 nM
98%
Megestrol
✔
98%
Bicalutamide
++
Androgen Receptor, IC50: 0.16 μM
99%
EPI-001
+
Androgen Receptor, IC50: ~6 μM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
N-desmethyl Enzalutamide 生物活性
描述
N-desmethyl Enzalutamide is an active metabolite of Enzalutamide, demonstrating primary and secondary pharmacodynamics similar in potency to Enzalutamide itself. It circulates in plasma at concentrations comparable to those of Enzalutamide[1]
体内研究
This metabolite is thought to contribute significantly to the clinical effects of Enzalutamide due to its similar pharmacological activity and plasma levels. In contrast, the carboxylic acid metabolite of Enzalutamide is pharmacologically inactive and circulates at plasma concentrations approximately 25% lower than those of Enzalutamide[1]
N-desmethyl Enzalutamide 参考文献
N-desmethyl Enzalutamide 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.22mL
0.44mL
0.22mL
11.10mL
2.22mL
1.11mL
22.20mL
4.44mL
2.22mL
N-desmethyl Enzalutamide 技术信息
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