Motolimod
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货号：A388121
同义名：
VTX-2337;VTX-378
Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities.
Motolimod 化学结构
Motolimod 3D分子结构
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Motolimod 纯度/质量文件 产品仅供科研
货号：A388121
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产品说明书
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Motolimod 质控信息
Motolimod 生物活性
描述
The toll-like receptors (TLR) are a family of protein that are responsible for pathogen recognition. TLR8 is expressed within the endolysosomal compartmental pathway and it is able to recognize the intracellular pathogens[3] [4] [5] [6]
作用机制
Motolimod is an ultra-potent TLR8 selective agonist by binding with the TLR-8[7]
Motolimod 动物研究
Dose
Monkey: 1 mg/kg, 10 mg/kg[1]
Administration
s.c.
Motolimod 参考文献
[1] Dietsch GN, Lu H, et al. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11(2):e0148764.
[2] Lu H, Dietsch GN, et al. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509.
[3] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010 May;11(5):373-84.
[4] Lu H, Dietsch GN, Matthews MA, Yang Y, Ghanekar S, Inokuma M, Suni M, Maino VC, Henderson KE, Howbert JJ, Disis ML, Hershberg RM. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509.
[5] Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11(2):e0148764.
[6] Zhang ZJ, Guo JS, Li SS, Wu XB, Cao DL, Jiang BC, Jing PB, Bai XQ, Li CH, Wu ZH, Lu Y, Gao YJ. TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG. J Exp Med. 2018 Dec 3;215(12):3019-3037.
[7] Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O. The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One. 2013;8(3):e58164.
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Motolimod 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.18mL
0.44mL
0.22mL
10.90mL
2.18mL
1.09mL
21.81mL
4.36mL
2.18mL
Motolimod 技术信息
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