Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant[3]. Mephenesin also inhibited MSR (mono-synaptic reflex) and PSR (poly-synaptic reflex), though the effects were short in duration. Both CPC (chlorphenesin carbamate) and mephenesin inhibit the firing of motoneurons by stabilizing the neuronal membrane, while mephenesin additionally suppresses the dorsal root reflex and the excitability of the primary afferent terminal[4]. The marked dependence on structure of the anticonvulsant activity of the mephenesin isomers can be interpreted as evidence that pressure acts not by some general perturbation of the membranes of excitable cells but rather via some specific interaction[5]. The spontaneous firings of the VB nociceptive neurons were depressed by both CPC (50 mg/kg, i.v.) and mephenesin (50 mg/kg, i.v.). However, mephenesin (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also depressed the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic rats[6]. Mephenesin (40 and 80 mg/kg, i.v.) depressed the amplitude of the fEMG (flexor EMG: fEMG) dose-dependently[7].
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