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褪黑素 /Melatonin {[allProObj[0].p_purity_real_show]}

货号：A204285 同义名： 松果体素 / N-Acetyl-5-methoxytryptamine;NSC 56423 Ambeed 开学季，买赠积分，赢豪礼

Melatonin is a hormone which plays a role in natural sleep-wake cycle and also a ATF6 blocker.

Melatonin 化学结构 CAS号：73-31-4
Melatonin 化学结构
CAS号：73-31-4
Melatonin 3D分子结构
CAS号：73-31-4
Melatonin 化学结构 CAS号：73-31-4
Melatonin 3D分子结构 CAS号：73-31-4
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Melatonin 生物活性

描述 Activating transcription factor 6 (ATF-6) is one of the three main endoplasmic reticulum(ER) transmembrane sensors that elicit the unfolded protein response(UPR). Melatonin (N-acetyl-5-methoxytryptamine), produced in the human pineal gland during the night phase of the light-dark cycle, plays important roles in physiological and pharmacological functions and also acts as a novel selective ATF-6 inhibitor. Melatonin treatment (10-5 mM) for 24 h after pretreatment by tunicamycin inhibited the expression COX-2 by downregulating ATF-6, which increased the apoptosis of HepG2 cells via CHOP and Bcl-2/Bax pathway[4]. Melatonin was an effective free radical scavenger and antioxidant which reduced amyloid β protein toxicity of Alzheimer’s disease, reduced oxidative damage in several models of Parkinson’s disease, protected against glutamate excitotoxicity, reduced ischemia-reperfusion injury, lowered neural damage due to d-aminolevulinic acid (phorphyria), hyperbaric hyperoxia and a variety of neural toxins. It also had been shown to reduce lipid peroxidation and oxidative damage to nuclear DNA[5].

Melatonin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
CHO cells Function assay Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells, Ki=8.00E-05 μM 9435890
CHO-Galpha16 cells Function assay 20 mins Binding affinity to rat MT1 receptor expressed in CHO-Galpha16 cells assessed as Ca2+ mobilization after 20 mins by FLIPR assay, EC50=0.56 nM 21237644
CHOK1 Function assay 3 h Displacement of [125I]2-iodomelatonin from human recombinant melatonin receptor 1 expressed in CHOK1 cells after 3 hrs, IC50=0.21 nM 23403082
HEK293 cells Function assay Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand), Ki=0.2 nM 11063602

Melatonin 动物研究

Dose Mice: 1 mg/kg - 50 mg/kg[4] (i.p.)
Administration i.p.

Melatonin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00869128 Diabetes Mellitus, Type 2 ... 展开 >> Insomnia 收起 << Phase 2 Completed - -
NCT00869128 - Completed - -
NCT02500017 Night-eating Syndrome Not Applicable Terminated(Difficulty recruiti... 展开 >>ng appropriate participants) 收起 << - United States, Connecticut ... 展开 >> Connecticut Mental Health Center New Haven, Connecticut, United States, 06519 收起 <<

Melatonin 参考文献

[1]Reiter RJ, Tan DX, et al. Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci. 2000 Nov-Dec;7(6):444-58.

[2]Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol. 1998 Oct;56(3):359-84.

[3]Bu LJ, Yu HQ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017;23(6):986-998.

[4]Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998. doi: 10.3748/wjg.v23.i6.986. PMID: 28246472; PMCID: PMC5311108.

[5]Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol. 1998 Oct;56(3):359-84. doi: 10.1016/s0301-0082(98)00052-5. PMID: 9770244.

Melatonin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.31mL

0.86mL

0.43mL

21.53mL

4.31mL

2.15mL

43.05mL

8.61mL

4.31mL

Melatonin 技术信息

CAS号73-31-4
分子式C13H16N2O2
分子量 232.28
别名 松果体素 ;N-Acetyl-5-methoxytryptamine;NSC 56423;5-Methoxy-N-acetyltryptamine;Circadin;Melatonine;Regulin;NSC 113928
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(452.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(4.31 mM)，配合低频超声助溶

无水乙醇: 12 mg/mL(51.66 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Melatonin | N-Acetyl-5-methoxytryptamine;NSC 56423;5-Methoxy-N-acetyltryptamine;Circadin;Melatonine;Regulin;NSC 113928 | 松果体素 | Drug Standard | Other Compounds | MT Receptor | AmBeed-信号通路专用抑制剂 | Melatonin 纯度/质量文件 | Melatonin 生物活性 | Melatonin 细胞研究 | Melatonin 动物研究 | Melatonin 临床数据 | Melatonin 参考文献 | Melatonin 实验方案 | Melatonin 技术信息

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