There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
ML162, a covalent inhibitor of glutathione peroxidase 4 (GPX4), exhibits selective toxicity towards cell lines expressing mutant RAS oncogenes[1][2]. It demonstrates nanomolar efficacy against two cell lines harboring HRASG12V, with IC50 values of 25 nM for HRASG12V-expressing cells and 578 nM for wild-type BJ fibroblasts[1]. Treatment with ML162 (8 μM for 24 hours) elevates p62 and Nrf2 levels in chemoresistant HN3R and HN3-rslR cells, deactivates Keap1, and enhances the phospho-PERK-ATF4-SESN2 signaling pathway[2]. ML162 variably induces cell death in head and neck cancer (HNC) cells, with the original HN3 cells being more susceptible, while the cisplatin-resistant HN3R and RSL3-resistant HN3-rslR cells show reduced sensitivity[2].
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