There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
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{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Ferroptosis ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ferrostatin-1 |
++
Ferroptosis, EC50: 60 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Liproxstatin-1 |
+++
ferroptosis, IC50: 22 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | ML162, a covalent inhibitor of glutathione peroxidase 4 (GPX4), exhibits selective toxicity towards cell lines expressing mutant RAS oncogenes[1][2]. It demonstrates nanomolar efficacy against two cell lines harboring HRASG12V, with IC50 values of 25 nM for HRASG12V-expressing cells and 578 nM for wild-type BJ fibroblasts[1]. Treatment with ML162 (8 μM for 24 hours) elevates p62 and Nrf2 levels in chemoresistant HN3R and HN3-rslR cells, deactivates Keap1, and enhances the phospho-PERK-ATF4-SESN2 signaling pathway[2]. ML162 variably induces cell death in head and neck cancer (HNC) cells, with the original HN3 cells being more susceptible, while the cisplatin-resistant HN3R and RSL3-resistant HN3-rslR cells show reduced sensitivity[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.47mL 2.09mL 1.05mL |
20.95mL 4.19mL 2.09mL |
CAS号 | 1035072-16-2 |
分子式 | C23H22Cl2N2O3S |
分子量 | 477.403 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(219.94 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |