Lusutrombopag | 鲁索曲波帕 | S-888711 | Thrombopoietin Receptor Agonist

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芦曲泊帕 /Lusutrombopag 99%+

货号：A215820 同义名： 鲁索曲波帕 / S-888711;Mulpleta

Lusutrombopag is an agonist of bioavailablethrombopoietin (TPO) receptor that is used to treat chronic liver disease.

Lusutrombopag 化学结构
CAS号：1110766-97-6

Lusutrombopag 3D分子结构
CAS号：1110766-97-6

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Lusutrombopag 纯度/质量文件产品仅供科研

货号：A215820 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Lusutrombopag 生物活性

描述

Thrombopoietin (TPO) plays an important role in regulating thrombopoiesis and is a proven therapeutic target to stimulate production of platelets. Lusutrombopag, a small-molecule, TPO receptor agonist, was evaluated as a treatment to raise platelet counts (PCs) in patients with thrombocytopenia and CLD (chronic liver disease) undergoing invasive procedures. Adults with CLD and baseline PCs < 50 × 10⁹/L were randomized to receive once‐daily lusutrombopag 3 mg or placebo ≤ 7 days before an invasive procedure scheduled 2‐7 days after the last dose. 64.8% (70/108) of patients in the lusutrombopag group versus 29.0% (31/107) in the placebo group met the primary endpoint (P < 0.0001; difference of proportion 95% confidence interval [CI], 36.7 [24.9, 48.5]). The median duration of PCs ≥ 50 × 10⁹/L was 19.2 days with lusutrombopag (without platelet transfusion) compared with 0.0 in the placebo group (with platelet transfusion) (P = 0.0001). Those date indicated that lusutrombopag was superior to placebo for reducing the need for platelet transfusions and achieved durable PC response in patients with thrombocytopenia and CLD undergoing invasive procedures ^[3].

Lusutrombopag 参考文献

[1]Katsube T, Ishibashi T, et al. Population Pharmacokinetic and Pharmacodynamic Modeling of Lusutrombopag, a Newly Developed Oral Thrombopoietin Receptor Agonist, in Healthy Subjects. Clin Pharmacokinet. 2016 Nov;55(11):1423-1433.

[2]Kim ES. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8.

[3]Peck-Radosavljevic M. Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L-PLUS 2). Hepatology. 2019 Oct;70(4):1336-1348. doi: 10.1002/hep.30561. Epub 2019 Mar 15.

Lusutrombopag 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.90mL

3.38mL

1.69mL

Lusutrombopag 技术信息

CAS号	1110766-97-6
分子式	C₂₉H₃₂Cl₂N₂O₅S
分子量	591.546

别名	鲁索曲波帕 ;S-888711;Mulpleta;Lusutrombopag, brand name: Mulpleta.
运输	蓝冰

存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 35 mg/mL(59.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

芦曲泊帕 /Lusutrombopag 99%+

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芦曲泊帕 /Lusutrombopag 99%+

Lusutrombopag 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Lusutrombopag 质控信息

Lusutrombopag 生物活性

Lusutrombopag 参考文献

Lusutrombopag 实验方案

Lusutrombopag 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Lusutrombopag 纯度/质量文件产品仅供科研