Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 / 免疫/炎症 / 血小板生成素受体 / Lusutrombopag

芦曲泊帕 /Lusutrombopag {[allProObj[0].p_purity_real_show]}

货号：A215820 同义名： 鲁索曲波帕 / S-888711;Mulpleta

Lusutrombopag is an agonist of bioavailablethrombopoietin (TPO) receptor that is used to treat chronic liver disease.

Lusutrombopag 化学结构 CAS号：1110766-97-6
Lusutrombopag 化学结构
CAS号：1110766-97-6
Lusutrombopag 3D分子结构
CAS号：1110766-97-6
Lusutrombopag 化学结构 CAS号：1110766-97-6
Lusutrombopag 3D分子结构 CAS号：1110766-97-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Lusutrombopag 纯度/质量文件 产品仅供科研

货号：A215820 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell Host Microbe, 2024. Ambeed. [ A163338 ]
• Cancer Res., 2024. Ambeed. [ A295334 ]
• J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
• J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
• JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >

Lusutrombopag 生物活性

描述 Thrombopoietin (TPO) plays an important role in regulating thrombopoiesis and is a proven therapeutic target to stimulate production of platelets. Lusutrombopag, a small-molecule, TPO receptor agonist, was evaluated as a treatment to raise platelet counts (PCs) in patients with thrombocytopenia and CLD (chronic liver disease) undergoing invasive procedures. Adults with CLD and baseline PCs < 50 × 109/L were randomized to receive once‐daily lusutrombopag 3 mg or placebo ≤ 7 days before an invasive procedure scheduled 2‐7 days after the last dose. 64.8% (70/108) of patients in the lusutrombopag group versus 29.0% (31/107) in the placebo group met the primary endpoint (P < 0.0001; difference of proportion 95% confidence interval [CI], 36.7 [24.9, 48.5]). The median duration of PCs ≥ 50 × 109/L was 19.2 days with lusutrombopag (without platelet transfusion) compared with 0.0 in the placebo group (with platelet transfusion) (P = 0.0001). Those date indicated that lusutrombopag was superior to placebo for reducing the need for platelet transfusions and achieved durable PC response in patients with thrombocytopenia and CLD undergoing invasive procedures [3].

Lusutrombopag 参考文献

[1]Katsube T, Ishibashi T, et al. Population Pharmacokinetic and Pharmacodynamic Modeling of Lusutrombopag, a Newly Developed Oral Thrombopoietin Receptor Agonist, in Healthy Subjects. Clin Pharmacokinet. 2016 Nov;55(11):1423-1433.

[2]Kim ES. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8.

[3]Peck-Radosavljevic M. Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L-PLUS 2). Hepatology. 2019 Oct;70(4):1336-1348. doi: 10.1002/hep.30561. Epub 2019 Mar 15.

Lusutrombopag 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.90mL

3.38mL

1.69mL

Lusutrombopag 技术信息

CAS号1110766-97-6
分子式C29H32Cl2N2O5S
分子量 591.546
别名 鲁索曲波帕 ;S-888711;Mulpleta;Lusutrombopag, brand name: Mulpleta.
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 35 mg/mL(59.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Lusutrombopag | 1110766-97-6 | S-888711 | S888711 | S 888711 | Thrombopoietin Receptor Agonist | Immunology/Inflammation | Thrombopoietin Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Lusutrombopag 纯度/质量文件 | Lusutrombopag 生物活性 | Lusutrombopag 参考文献 | Lusutrombopag 实验方案 | Lusutrombopag 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z