APE1 is an enzyme that is involve in the DNA base excision repair pathway. Its main role in the repair of damaged or mismatched nucleotides in DNA is to create a nick in the phosphodiester backbone of the AP site created when DNA glycosylase removes the damaged base[1]. Lucanthone is a novel autophagic inhibitor which also inhibits APE1by direct protein binding without affecting its redox activity. It induces apoptosis via cathepsin D accumulation and enhance histone deacetylase inhibitor-induced cell death in MDA-MB-231 cells. Combined treatment with lucanthone and TRAIL significantly induced apoptosis in human renal carcinoma, prostate carcinoma and lung carcinoma cells[2]. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ[3].
Withdrawn(Pending resolution o... 展开 >>f study drug issues) 收起 <<
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United States, North Carolina
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Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
United States, California
... 展开 >>
UCSD Moores Cancer Center
La Jolla, California, United States, 92093
UCI Medical Center
Orange, California, United States, 92868
United States, New York
Dent Neurologic Institute
Amherst, New York, United States, 14226
United States, Ohio
Fairview Hospital Moll Cancer Center/Cleveland Clinic
Cleveland, Ohio, United States, 44111
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Hillcrest Hospital Hirsh Cancer Center/Cleveland Clinic
Mayfield, Ohio, United States, 44124
India
Gujarat Cancer Research Institute
Ahmedabad, Gujarat, India, 380016
Jaslok Hospital & Research Centre
Mumbai, Maharashtra, India, 400062
Bhagwan Mahaveer Cancer Hospital & Reseach Centre
Jaipur, Rajasthan, India, 302017
Chittaranjan National Cancer Institute
Kolkata, West Bengal, India, 700026 收起 <<
Withdrawn(Pending resolution o... 展开 >>f study drug issues) 收起 <<
-
United States, North Carolina
... 展开 >>
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
United States, California
... 展开 >>
UCSD Moores Cancer Center
La Jolla, California, United States, 92093
UCI Medical Center
Orange, California, United States, 92868
United States, New York
Dent Neurologic Institute
Amherst, New York, United States, 14226
United States, Ohio
Fairview Hospital Moll Cancer Center/Cleveland Clinic
Cleveland, Ohio, United States, 44111
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Hillcrest Hospital Hirsh Cancer Center/Cleveland Clinic
Mayfield, Ohio, United States, 44124
India
Gujarat Cancer Research Institute
Ahmedabad, Gujarat, India, 380016
Jaslok Hospital & Research Centre
Mumbai, Maharashtra, India, 400062
Bhagwan Mahaveer Cancer Hospital & Reseach Centre
Jaipur, Rajasthan, India, 302017
Chittaranjan National Cancer Institute
Kolkata, West Bengal, India, 700026 收起 <<
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