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描述 | Lonidamine is a selective inhibitor that inhibits aerobic glycolysis in murine tumor cells. Lonidamine at a concentration of 0.32mM reduced the respiration of germ cells and submaxillary gland cells by 58%. Treatment of Serotoli’s cells and hepatocytes with lonidamine led to 16% and 6% inhibition of oxygen consumption, respectively. Lonidamine at the same concentration inhibited oxygen consumption of Ehrlich ascites tumor cells and sarcoma 180 cells by 58 and 63%, respectively, but enhanced aerobic glycolysis in normal cells, such as germ cells (57%) and submaxillary gland cells (35%). Lonidamine at a concentration of 20mM reduced the amount of glucose 6-phosphate formed by the mitochondria of Ehrlich ascites tumor cells by >50%.[2] Lonidamine inhibited glioma cell proliferation with an IC50 value of 200μM. Treatment of SNb-19 cells with 100 or 200μM lonidamine resulted in a slight decrease in the S-phase component of the cell cycle (3% and 9%, respectively). The administration of nude mice with lonidamine (160 mg/kg body weight/day) and diazepam (1 mg/kg body weight/day) via intraperitoneal injection for 10 days inhibited the growth of TG-8-OZ glioma xenograft (78% inhibition) 7 days after the treatment.[1] |
作用机制 | Lonidamine is a derivative of indazole-3-carboxylic acid that affects energy metabolism in tumor cells by inhibiting mitochondria-bound hexokinase and the electron transport chain.[1] |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.11mL 0.62mL 0.31mL |
15.57mL 3.11mL 1.56mL |
31.14mL 6.23mL 3.11mL |
CAS号 | 50264-69-2 |
分子式 | C15H10Cl2N2O2 |
分子量 | 321.158 |
别名 | AF-1890;Diclondazolic Acid;Doridamina;DICA |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(155.69 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 2% DMSO+2% Tween80+40% PEG300+water 7 mg/mL clear PO 0.5% CMC-Na 42 mg/mL suspension |