Antipyrine (Phenazone) serves as both an antipyretic and an analgesic. It is commonly utilized as a probe agent for studying the metabolism of oxidative agents, playing a significant role in assessing hepatic oxidative capacity[1].[2].
体内研究
In dietary studies, lithocholic acid at a concentration of 0.6% in the diet over a period of 7 days leads to increased mRNA levels of TGFB1, TGFBR1, and TGFBR2 in the liver of male C57BL/6 mice, activates SMAD3, and results in biliary injury[4].
Additionally, an intraperitoneal dose of 125 mg/kg administered twice daily for four days results in liver damage in male C57BL/6 mice, marked by elevated levels of AST, ALT, and ALP[2].
体外研究
Lithocholic acid inhibits FXR activation induced by CDCA and GW4064, with IC50 values of 0.7 μM and 1.4 μM, respectively[5].
Lithocholic acid also suppresses GW4064-induced BSEP expression at concentrations of 10-30 μM over 24 hours in HepG2 cells[5].
Furthermore, lithocholic acid inhibits the proliferation of various neuroblastoma cell lines (BE(2)-M17, SK-n-SH, SK-n-MCIXC, and Lan-1) in a dose-dependent manner, up to 500 μM[3].
搜索
