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醋酸兰瑞肽 /Lecirelin {[allProObj[0].p_purity_real_show]}

货号:A489833 同义名: Lecirelin游离态 Ambeed 开学季,买赠积分,赢豪礼

Lecirelin is a synthetic GnRH analogue which showed a great efficacy in the treatment of bovine ovarian follicular cysts.

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Lecirelin 化学结构 CAS号:61012-19-9
Lecirelin 化学结构
CAS号:61012-19-9
Lecirelin 3D分子结构
CAS号:61012-19-9
Lecirelin 化学结构 CAS号:61012-19-9
Lecirelin 3D分子结构 CAS号:61012-19-9
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Lecirelin 纯度/质量文件 产品仅供科研

货号:A489833 标准纯度: {[allProObj[0].p_purity_real_show]}
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Lecirelin 生物活性

描述 Lecirelin is a synthetic gonadotropin releasing hormone (GnRH) analogue which commonly used in the treatment of bovine ovarian follicular cysts. The treatment of choice is intramuscular administration of lecirelin. However, the epidural administration of lecirelin promoted the remission of follicular cysts and an improvement of reproductive parameters compared to intramuscular administration[2]. There was a significantly lower LH release after gonadorelin treatment compared to lecirelin at the doses of 25 or 50 μg and the buserelin treatment[3]. The percentage of disappearance of the dominant follicle (84.8% of ovulation and 4.3% of luteinization) after GnRH treatment was high (82% and 100%, for lecirelin at the doses of 25 and 50 μg respectively). Lecirelin, at the doses indicated for the induction of ovulation, is almost equally effective to induce the disappearance of the dominant follicle at Day 6 to 7 of the estrous cycle[3]. Lecirelin modulates the contractility of the bovine ovarian follicular wall; in basal conditions and after the addition of lecirelin, the strips from preovulatory follicles contract significantly more than strips from cysts[4].

Lecirelin 参考文献

[1]Dal Bosco A, Cardinali R, et al. Induction of ovulation in rabbits by adding Lecirelin to the seminal dose: in vitro and in vivo effects of different excipients. Anim Reprod Sci. 2014 Nov 10;150(1-2):44-9.

[2]Rizzo A, Campanile D, Mutinati M, Minoia G, Spedicato M, Sciorsci RL. Epidural vs intramuscular administration of lecirelin, a GnRH analogue, for the resolution of follicular cysts in dairy cows. Anim Reprod Sci. 2011 Jun;126(1-2):19-22. doi: 10.1016/j.anireprosci.2011.04.013. Epub 2011 Apr 29. Erratum in: Anim Reprod Sci. 2012 Mar;131(1-2):107. Annalisa, Rizzo [corrected to Rizzo, Annalisa]; Debora, Campanile [corrected to Campanile, Debora]; Maddalena, Mutinati [corrected to Mutinati, Maddalena]; Giuseppe, Minoia [corrected to Minoia, Giuseppe]; Massimo, Spedicato [corrected to Spedicato, Massim. PMID: 21571459.

[3]Picard-Hagen N, Lhermie G, Florentin S, Merle D, Frein P, Gayrard V. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle. Theriogenology. 2015 Jul 15;84(2):177-83. doi: 10.1016/j.theriogenology.2015.03.004. Epub 2015 Mar 14. PMID: 25890780.

[4]Rizzo A, Cosola C, Mutinati M, Spedicato M, Minoia G, Sciorsci RL. Bovine ovarian follicular cysts: in vitro effects of lecirelin, a GnRH analogue. Theriogenology. 2010 Dec;74(9):1559-69. doi: 10.1016/j.theriogenology.2010.06.026. Epub 2010 Aug 5. PMID: 20691467.

Lecirelin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.83mL

0.17mL

0.08mL

4.13mL

0.83mL

0.41mL

8.27mL

1.65mL

0.83mL

Lecirelin 技术信息

CAS号61012-19-9
分子式C59H84N16O12
分子量 1209.398
别名 Lecirelin游离态
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 12 mg/mL(9.92 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 25 mg/mL(20.67 mM),配合低频超声助溶

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