货号:A122807
同义名:
Kanamycin A sulfate; Kanamycin A(sulfate)
Kanamycin sulfate是一种氨基糖苷类抗生素,通过靶向结合细菌70S核糖体亚基,抑制核糖体易位和干扰蛋白合成,对革兰氏阳性/阴性菌及支原体都有效。Kanamycin sulfate用于细菌污染控制、抗性基因(kan)的细菌克隆筛选,以及npt II(APH3)基因标记的农杆菌转化植物组织的选择性培养。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
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描述 | Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. KS is polycationic, a property responsible for KS poor oral absorption half-life (2.5 h) and rapid renal clearance, which results in serious nephrotoxicity/ototoxicity[3]. Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration[4]. The neurons damage of the DCN (dorsal cochlear nucleus) caused by kanamycin was reversible and autophagy was upregulated in the neurotoxic course of kanamycin on DCN[5]. Moreover, with perfusion of kanamycin 10 mM in the endolymphatic space, the EP (endocochlear dc potential) declined severely[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02496572 | - | Unknown | April 2016 | Uzbekistan ... 展开 >> Outpatient clinics in three districts Nukus, Karakalpakstan, Uzbekistan 收起 << | |
NCT02975570 | Tuberculosis Multi Drug Resist... 展开 >>ant Active 收起 << | Phase 3 | Withdrawn(The study could not ... 展开 >>be conducted since funding was not obtained.) 收起 << | August 2022 | - |
NCT03237182 | Tuberculosis, Multidrug-Resist... 展开 >>ant 收起 << | Phase 4 | Recruiting | December 2021 | South Africa ... 展开 >> King Dinuzulu Hospital Recruiting Durban, Kwa-Zulu Natal, South Africa Contact: Nesri Padayatchi, MBcHB 0312604550 nesri.padayatchi@caprisa.org Contact: Resha Boodhram, BTech 0828383651 resha.boodhram@caprisa.org 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.58mL 1.72mL 0.86mL |
17.17mL 3.43mL 1.72mL |
CAS号 | 25389-94-0 |
分子式 | C18H38N4O15S |
分子量 | 582.58 |
SMILES Code | O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](N)C[C@@H]2N.O=S(O)(O)=O |
MDL No. | MFCD00070253 |
别名 | Kanamycin A sulfate; Kanamycin A(sulfate); Ophtalmokalixan; Kanamycin monosulfate; Kanamycin(sulfate) |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |
溶解方案 |
H2O: 25 mg/mL(42.91 mM) |