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Kanamycin sulfate {[allProObj[0].p_purity_real_show]}

货号:A122807 同义名: Kanamycin A sulfate; Kanamycin A(sulfate)

Kanamycin sulfate是一种氨基糖苷类抗生素,通过靶向结合细菌70S核糖体亚基,抑制核糖体易位和干扰蛋白合成,对革兰氏阳性/阴性菌及支原体都有效。Kanamycin sulfate用于细菌污染控制、抗性基因(kan)的细菌克隆筛选,以及npt II(APH3)基因标记的农杆菌转化植物组织的选择性培养。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Kanamycin sulfate 化学结构 CAS号:25389-94-0
Kanamycin sulfate 化学结构
CAS号:25389-94-0
Kanamycin sulfate 3D分子结构
CAS号:25389-94-0
Kanamycin sulfate 化学结构 CAS号:25389-94-0
Kanamycin sulfate 3D分子结构 CAS号:25389-94-0
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Kanamycin sulfate 纯度/质量文件 产品仅供科研

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Kanamycin sulfate 生物活性

描述 Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. KS is polycationic, a property responsible for KS poor oral absorption half-life (2.5 h) and rapid renal clearance, which results in serious nephrotoxicity/ototoxicity[3]. Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration[4]. The neurons damage of the DCN (dorsal cochlear nucleus) caused by kanamycin was reversible and autophagy was upregulated in the neurotoxic course of kanamycin on DCN[5]. Moreover, with perfusion of kanamycin 10 mM in the endolymphatic space, the EP (endocochlear dc potential) declined severely[6].

Kanamycin sulfate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02496572 - Unknown April 2016 Uzbekistan ... 展开 >> Outpatient clinics in three districts Nukus, Karakalpakstan, Uzbekistan 收起 <<
NCT02975570 Tuberculosis Multi Drug Resist... 展开 >>ant Active 收起 << Phase 3 Withdrawn(The study could not ... 展开 >>be conducted since funding was not obtained.) 收起 << August 2022 -
NCT03237182 Tuberculosis, Multidrug-Resist... 展开 >>ant 收起 << Phase 4 Recruiting December 2021 South Africa ... 展开 >> King Dinuzulu Hospital Recruiting Durban, Kwa-Zulu Natal, South Africa Contact: Nesri Padayatchi, MBcHB    0312604550    nesri.padayatchi@caprisa.org    Contact: Resha Boodhram, BTech    0828383651    resha.boodhram@caprisa.org 收起 <<

Kanamycin sulfate 参考文献

[1]Fan GR, Yin ZD, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013 Jan 17. pii: S0006-8993(13)00068-1.

[2]Adams E, Dalle J, et al. Analysis of kanamycin sulfate by liquid chromatography with pulsed electrochemical detection. J Chromatogr A. 1997 Apr 4;766(1-2):133-9.

[3]Walker EH, Pacold ME, Perisic O, et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell. 2000;6(4):909-19

[4]Yin Z, Kng W. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012;26(10):478–480.

[5]Fan GR, Yin ZD, Sun Y, et al. Reversible neurotoxicity of kanamycin on dorsal cochlear nucleus. Brain Res. 2013;1502:30–46.

[6]Komune S, Snow JB Jr. Ototoxicity of kanamycin sulfate and the barriers in the inner ear. Otolaryngol Head Neck Surg. 1981;89(6):1013–1018.

Kanamycin sulfate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.58mL

1.72mL

0.86mL

17.17mL

3.43mL

1.72mL

Kanamycin sulfate 技术信息

CAS号25389-94-0
分子式C18H38N4O15S
分子量 582.58
SMILES Code O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](N)C[C@@H]2N.O=S(O)(O)=O
MDL No. MFCD00070253
别名 Kanamycin A sulfate; Kanamycin A(sulfate); Ophtalmokalixan; Kanamycin monosulfate; Kanamycin(sulfate)
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

H2O: 25 mg/mL(42.91 mM)

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