Compounds based on indazole, including Axitinib, Lonidamine, and Pazopanib, have shown promising anticancer activities in research, positioning indazole derivatives as valuable scaffolds for the development of new anticancer medications^[1].

Indazole derivatives are also effective against neurological disorders, primarily by inhibiting enzymes such as monoamine oxidase (MAO), Glycogen synthase kinase 3 (GSK3), and Leucine-rich repeat kinase enzyme 2 (LRRK2)^[2].

Noteworthy among natural and synthetic indazole derivatives are Nigellicine, Nigellamine, Nigellidine, Zanubrutinib, and SCH772984, which have demonstrated significant efficacy in treating various gastrointestinal disorders^[4].