Ambeed.cn

首页 / 抑制剂/激动剂 / PI3K/Akt/mTOR / PI4K / ISA-2011B

ISA-2011B游离态 /ISA-2011B {[allProObj[0].p_purity_real_show]}

货号:A899194

ISA-2011B is a PIP5Kα (Phosphatidylinositol-4-phosphate 5-kinase-α) inhibitor.

ISA-2011B 化学结构 CAS号:1395347-24-6
ISA-2011B 化学结构
CAS号:1395347-24-6
ISA-2011B 3D分子结构
CAS号:1395347-24-6
ISA-2011B 化学结构 CAS号:1395347-24-6
ISA-2011B 3D分子结构 CAS号:1395347-24-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

ISA-2011B 纯度/质量文件 产品仅供科研

货号:A899194 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]
Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]
ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]
ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]
Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]
更多 >

ISA-2011B 生物活性

描述 Phosphatidylinositol 4,5-biphosphate kinases (PIP5Ks) are a family of lipid kinases that phosphorylate phosphatidylinositol 4-phosphate on the D5 position of the inositol ring, thus inducing the production of phosphatidylinositol 4,5-biphosphate (PIP2). PIP5K1α is a lipid kinase that acts on PI3K/AKT/PTEN pathways, and thereby regulates cell survival and migration. ISA-2011B is a PIP5Kα inhibitor with promising anticancer effects. Tumor xenografts established with human prostatic carcinoma cell line 22Rv1 were treated with ISA-2011B(40 mg/kg, 2 weeks) and showed a 3.5-fold smaller tumor volumes compared with those treated with vehicle control (mean volume of tumors were 844.12 mm3 and 243.77 mm3 for vehicle-treated and ISA-2011B-treated groups, respectively)[3]. ISA-2011B treatment at 20 mM or 50 mM diminished AR-V7, CDK1 and PSA expression in PIP5K1α-overexpressing and control 22Rv1 cells, and inhibited AR-V7 and pAKT expression in PC3 cells, respectively[3]. ISA-2011B treatment at 10 µM for 6h or 24h significantly impaired the increases in mRNA levels of IL-6, IL-8, and IL-17A in T lymphocytes from healthy donors which were induced by CD38 stimulation[4]. ISA-2011B at 20 μM dramatically inhibited pSer-473 AKT by 75.55% compared with control in LNCaP cells[5].

ISA-2011B 参考文献

[1]Kunkl M, Porciello N, et al. ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes. Front Immunol. 2017 Apr 26;8:502.

[2]Sarwar M, Semenas J, et al. Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells. Oncotarget. 2016 Sep 27;7(39):63065-63081.

[3]Sarwar M, Semenas J, Miftakhova R, Simoulis A, Robinson B, Gjörloff Wingren A, Mongan NP, Heery DM, Johnsson H, Abrahamsson PA, Dizeyi N, Luo J, Persson JL. Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells. Oncotarget. 2016 Sep 27;7(39):63065-63081. doi: 10.18632/oncotarget.11757. PMID: 27588408; PMCID: PMC5325347.

[4]Kunkl M, Porciello N, Mastrogiovanni M, Capuano C, Lucantoni F, Moretti C, Persson JL, Galandrini R, Buzzetti R, Tuosto L. ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes. Front Immunol. 2017 Apr 26;8:502. doi: 10.3389/fimmu.2017.00502. PMID: 28491063; PMCID: PMC5405084.

[5]Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL. The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98. doi: 10.1073/pnas.1405801111. Epub 2014 Jul 28. PMID: 25071204; PMCID: PMC4156761.

ISA-2011B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.80mL

2.36mL

1.18mL

23.59mL

4.72mL

2.36mL

ISA-2011B 技术信息

CAS号1395347-24-6
分子式C22H18ClN3O4
分子量 423.849
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

DMSO: 105 mg/mL(247.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。