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醋酸氢化可的松 /Hydrocortisone Acetate {[allProObj[0].p_purity_real_show]}

货号:A420646 同义名: Hydrocortisone 21-acetate;Cortisol 21-acetate

Hydrocortisone acetate, the acetate salt form of hydrocortisone, is a corticosteroid with anti-inflammatory and is used to decrease swelling, itching, and pain.

Hydrocortisone Acetate 化学结构 CAS号:50-03-3
Hydrocortisone Acetate 化学结构
CAS号:50-03-3
Hydrocortisone Acetate 3D分子结构
CAS号:50-03-3
Hydrocortisone Acetate 化学结构 CAS号:50-03-3
Hydrocortisone Acetate 3D分子结构 CAS号:50-03-3
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Hydrocortisone Acetate 纯度/质量文件 产品仅供科研

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Hydrocortisone Acetate 生物活性

描述 Hydrocortisone acetate (HCA) is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids. Pregnant rats were treated (s.c.) with hydrocortisone acetate, at 1.5 mg/day on the 17th, 18th, and 19th days of gestation. Decreased body weight and no alteration in anogenital distance were observed in male offspring. Adulthood, presented reductions of body weight, plasma testosterone levels, and seminal-vesicle wet weight without secretion as well as no alteration in the wet weights of the testes, epididymis, and seminal vesicle with secretion in the treated group. Males exposed to hydrocortisone during the prenatal period were able to mate with normal females, which became pregnant but exhibited an increased number of post-implantation losses[3]. The catabolic effects of hydrocortisone acetate on Longissimus dorsi muscle in pregnant rats can be observed from day 9 of treatment. The longer the treatment the higher the effect is[4].

Hydrocortisone Acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02090270 - Completed - Israel ... 展开 >> Meir Medical Center Kfar Saba, Israel 收起 <<
NCT02270827 - Terminated(Study was set up by... 展开 >> an MSc student who left her post.) 收起 << - United Kingdom ... 展开 >> Royal Brompton Hospital London, United Kingdom, sw3 6hp 收起 <<
NCT00709839 Healthy Phase 4 Completed - Austria ... 展开 >> Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna Vienna, Austria, A-1090 收起 <<

Hydrocortisone Acetate 参考文献

[1]Ascaso M, Perez-Lozano P, et al. Development and Validation of a Stability Indicating RP-HPLC Method for Hydrocortisone Acetate Active Ingredient, Propyl Parahydroxybenzoate and Methyl Parahydroxybenzoate Preservatives, Butylhydroxyanisole Antioxidant, and Their Degradation Products in a Rectal Gel Formulation. J AOAC Int. 2015 Jan-Feb;98(1):27-34.

[2]Kerslery GD, Desmarais MH. Intra-articular hydrocortisone acetate in rheumatoid arthritis. Lancet. 1952 Aug 9;2(6728):269.

[3]Pereira OC, Arena AC, Yasuhara F, Kempinas WG. Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats. Regul Toxicol Pharmacol. 2003 Aug;38(1):36-42

[4]Lopez-Jurado M, Aranda P, Montellano MA, Urbano G. Influence of hydrocortisone acetate of the longissimus dorsi muscle during gestation of rats. Nahrung. 1987;31(2):133-43

Hydrocortisone Acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.72mL

4.94mL

2.47mL

Hydrocortisone Acetate 技术信息

CAS号50-03-3
分子式C23H32O6
分子量 404.497
别名 Hydrocortisone 21-acetate;Cortisol 21-acetate;Isopto-Hydrocortisone;17α-Hydroxycorticosterone Acetate;Hydroxycorticosterone Acetate;Hydrin 2;Cortef Acetate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 40 mg/mL(98.89 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 5 mg/mL clear

PO 0.5% CMC-Na 40 mg/mL suspension

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