Hexaminolevulinate HCl is a fluorescent agent which has been approved for cystoscopic detection of papillary bladder cancer[3]. Clinical trials have shown that hexaminolevulinate (HAL) fluorescence cystoscopy improves the detection of bladder tumors compared with standard white-light cystoscopy, resulting in more efficacious treatment[4]. Exogenous administration of hexaminolevulinate induces fluorescent protoporphyrin IX (PpIX) accumulation preferentially in cancer cells. In some of the incubation conditions tested, the addition of DFO (deferoxamine) with HAL significantly increased PpIX 21 fluorescence of adherent monolayer cancer cells, but this was never the case for cells in suspension[5]. Blue light cystoscopy (BLC) with hexaminolevulinate during transurethral resection of bladder cancer improves detection of non-muscle-invasive bladder cancer (NMIBC) and reduces recurrence rates[6].
United States, California
... 展开 >>
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
United States, Illinois
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21205
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, New York
Montefiore Medical Center
Bronx, New York, United States, 10461
NYU Langone Urology Associates
New York, New York, United States, 10016
Columbia University Medical Center
New York, New York, United States, 10032
United States, North Carolina
University of North Carolina, Department of Urology
Chapel Hill, North Carolina, United States, 27599
United States, Ohio
Ohio State University The James Cancer Hospital
Columbus, Ohio, United States, 43210
United States, Oklahoma
University of Oklahoma-Stephenson Cancer Center
Oklahoma City, Oklahoma, United States, 73104
United States, Pennsylvania
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 10197
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
United States, Texas
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Michael E. DeBakey VA Medical Center
Houston, Texas, United States, 77030
United States, Wisconsin
University of Wisconsin
Madison, Wisconsin, United States, 53792 收起 <<
Germany
... 展开 >> Medizinische Hochschule Hannover, Department of Obstetrics and Gynecology
Hannover, Germany, 30625
Norway
Ullevål University Hospital, Department of Obstetrics and Gynecology
Oslo, Norway, 0407 收起 <<
Terminated(Slow recruitment, s... 展开 >>tudy stopped with only 13 of 70 patients included in second part of the study) 收起 <<
-
France
... 展开 >> Department of Obstetrics and Gyneacology, Lille University Hospital
Lille, France
Germany
Department of Obstetrics and Gynecology
Hannover, Germany
Norway
Fritzøe klinikk
Larvik, Norway
Department of Obstetrics and Gynaecology, Ullevål University Hospital
Oslo, Norway
Medicus
Trondheim, Norway 收起 <<
United States, California
... 展开 >>
USC/Norris Comprehensive Cancer Center
Recruiting
Los Angeles, California, United States, 90033
Contact: Ileana Aldana 323-865-0702 ileana.aldana@med.usc.edu
Principal Investigator: Sia Daneshmand, MD
Sub-Investigator: Anne Schuckman, MD
Sub-Investigator: Mihir Desai, MD
Sub-Investigator: Hooman Djaladat, MD
Sub-Investigator: Gerhard Fuchs, MD
Sub-Investigator: Virinder Bhardwaj, MD
VA Palo Alto Health Care System
Recruiting
Palo Alto, California, United States, 94304
Contact: Dorothy Trivedi dtrivedi@stanford.edu
Principal Investigator: Joseph Liao, MD
Sub-Investigator: James Crotty, MD
Sub-Investigator: John Leppert, MD
Sub-Investigator: John Lavelle, MD
University of California, San Francisco
Recruiting
San Francisco, California, United States, 94143
Contact: Sima Porten, MD, MPH 415-885-3695 Sima.Porten@ucsf.edu
Principal Investigator: Sima Porten, MD, MPH
United States, Kansas
University of Kansas Medical Center
Recruiting
Kansas City, Kansas, United States, 66160
Contact: Katie Glavin 913-588-8721 kglavin@kumc.edu
Principal Investigator: John Taylor, MD, MS
Sub-Investigator: Jeffrey Holzbeierlein, MD, FACS
Sub-Investigator: Eugene Lee, MD, FACS
Sub-Investigator: Hadley Wyre, MD
Sub-Investigator: Moben Mirza, MD
United States, Maryland
Johns Hopkins Medicine
Recruiting
Baltimore, Maryland, United States, 21224
Contact: Morgan De Carli Mdecarl2@jhmi.edu
Principal Investigator: Trinity Bivalacqua, MD, PhD
Sub-Investigator: Phillip Pierorazio, MD
United States, Minnesota
University of Minnesota
Recruiting
Minneapolis, Minnesota, United States, 55455
Contact: Therese Perrier 612-625-3319 perri084@umn.edu
Principal Investigator: Badrinath Konety, MD
Sub-Investigator: Weight Chris, MD
Sub-Investigator: Laureen Hemsley, MD
United States, New York
Stony Brook Urology
Recruiting
Stony Brook, New York, United States, 11794
Contact: Kim Lyktey Kim.Lyktey@stonybrookmedicine.edu
Principal Investigator: John Fitzgerald, MD
Sub-Investigator: Massimiliano Spaliviero, MD
Sub-Investigator: Wayne Waltzer, MD
United States, Ohio
Cincinnati VA Medical Center
Not yet recruiting
Cincinnati, Ohio, United States, 45220
Contact: Krishnanath Gaitonde, MD
Principal Investigator: Krishnanath Gaitonde, MD
Ohio State University Wexner Medical Center
Recruiting
Columbus, Ohio, United States, 43210
Contact: Kamal Pohar, MD kamal.pohar@osumc.edu
Principal Investigator: Kamal Pohar, MD
Sub-Investigator: Megan Merrill, DO
Sub-Investigator: Ahmad Shabsigh, MD
Sub-Investigator: David Sharp, MD
United States, South Carolina
Carolina Urology Partners
Recruiting
West Columbia, South Carolina, United States, 29169
Contact: Nicol Brandon 704-414-2870 ext 2809 Nicol.brandon@carolinaurologypartners.com
Principal Investigator: T. Brian Willard, MD
Sub-Investigator: David Lamb, MD
Sub-Investigator: Scott Sweazy, MD
Sub-Investigator: Keith Birghtbill, MD
Sub-Investigator: Michael Stotzer, MD
United States, Texas
UT Southwestern
Not yet recruiting
Dallas, Texas, United States, 75390
Contact: Yair Lotan, MD 214-645-8787
Principal Investigator: Yair Lotan, MD
Sub-Investigator: Aditya Bagrodia, MD
Sub-Investigator: Vitaly Margulis, MD
Sub-Investigator: Ganesh Raj, MD, PhD
Michael E. DeBakey VA Medical Center
Recruiting
Houston, Texas, United States, 77030
Contact: Ashley Jones, BS, CCRP 713-791-1414 ext 26694 Ashley.Jones2@bcm.edu
Principal Investigator: Jennifer Taylor, MD, MPH
Sub-Investigator: Jeffrey Jones, MD
Sub-Investigator: Sidney Worsham, MD
United States, West Virginia
Charleston Area Medical Center
Recruiting
Charleston, West Virginia, United States, 25301
Contact: James Tierney, DO 304-388-9944
Principal Investigator: James Tierney, DO
Sub-Investigator: Samuel Deem, DO 收起 <<
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